Control of the size of the human muscle mass

M. J. Rennie, Henning Wackerhage, E. Spangenburg, F. W. Booth

Research output: Contribution to journalArticle

255 Citations (Scopus)

Abstract

This review is divided into two parts, the first dealing with the cell and molecular biology of muscle in terms of growth and wasting and the second being an account of current knowledge of physiological mechanisms involved in the alteration of size of the human muscle mass. Wherever possible, attempts have been made to interrelate the information in each part and to provide the most likely explanation 6 for phenomena that are currently only partially understood. The review should be of 6 interest to cell and molecular biologists who know little of human muscle physiology and to physicians, physiotherapists, and kinesiologists who may be familiar with the gross behavior of human muscle but wish to understand more about the underlying mechanisms of change.

Original languageEnglish
Pages (from-to)799-828
Number of pages29
JournalAnnual Review of Physiology
Volume66
DOIs
Publication statusPublished - Mar 2004

Keywords

  • adaptation
  • physical activity
  • nutrition
  • hypertrophy
  • protein turnover
  • HUMAN SKELETAL-MUSCLE
  • GROWTH-FACTOR-I
  • STIMULATES PROTEIN-SYNTHESIS
  • RAPAMYCIN-SENSITIVE PATHWAY
  • ACUTE RESISTANCE EXERCISE
  • AMINO-ACID INFUSION
  • GENE-EXPRESSION
  • PHYSICAL-ACTIVITY
  • IGF-I
  • BODY-COMPOSITION

Cite this

Rennie, M. J., Wackerhage, H., Spangenburg, E., & Booth, F. W. (2004). Control of the size of the human muscle mass. Annual Review of Physiology, 66, 799-828. https://doi.org/10.1146/annurev.physiol.66.052102.134444

Control of the size of the human muscle mass. / Rennie, M. J.; Wackerhage, Henning; Spangenburg, E.; Booth, F. W.

In: Annual Review of Physiology, Vol. 66, 03.2004, p. 799-828.

Research output: Contribution to journalArticle

Rennie, MJ, Wackerhage, H, Spangenburg, E & Booth, FW 2004, 'Control of the size of the human muscle mass', Annual Review of Physiology, vol. 66, pp. 799-828. https://doi.org/10.1146/annurev.physiol.66.052102.134444
Rennie, M. J. ; Wackerhage, Henning ; Spangenburg, E. ; Booth, F. W. / Control of the size of the human muscle mass. In: Annual Review of Physiology. 2004 ; Vol. 66. pp. 799-828.
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