Controlling cell behaviour electrically: current views and future potential

Research output: Contribution to journalArticle

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Abstract

Controlling Cell Behavior Electrically: Current Views and Future Potential. Physiol Rev 85: 943-978, 2005; doi:10.1152/physrev.00020.2004. -Direct-current ( DC) electric fields are present in all developing and regenerating animal tissues, yet their existence and potential impact on tissue repair and development are largely ignored. This is primarily due to ignorance of the phenomenon by most researchers, some technically poor early studies of the effects of applied fields on cells, and widespread misunderstanding of the fundamental concepts that underlie bioelectricity. This review aims to resolve these issues by describing: 1) the historical context of bioelectricity, 2) the fundamental principles of physics and physiology responsible for DC electric fields within cells and tissues, 3) the cellular mechanisms for the effects of small electric fields on cell behavior, and 4) the clinical potential for electric field treatment of damaged tissues such as epithelia and the nervous system.

Original languageEnglish
Pages (from-to)943-978
Number of pages35
JournalPhysiological Reviews
Volume85
Issue number3
DOIs
Publication statusPublished - Jul 2005

Keywords

  • GROWTH CONE GUIDANCE
  • LENS EPITHELIAL-CELLS
  • PROTEIN-COUPLED RECEPTORS
  • SPINAL-CORD HEMISECTION
  • FIELD-DIRECTED GROWTH
  • LEFT-RIGHT ASYMMETRY
  • NERVE GROWTH
  • NEUTROPHIL CHEMOTAXIS
  • CORNEAL EPITHELIUM
  • NEURITE GROWTH

Cite this

Controlling cell behaviour electrically: current views and future potential. / McCaig, Colin Darnley; Rajnicek, Ann Marie; Song, Bing; Zhao, Min.

In: Physiological Reviews, Vol. 85, No. 3, 07.2005, p. 943-978.

Research output: Contribution to journalArticle

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