Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference

Hitten P. Zaveri; Bjoern Schelter; Catherine A. Schevon; Premysl Jiruska; John G. R. Jefferys; Gregory Worrell; Andreas Schulze-Bonhage; Rasesh B. Joshi; Viktor Jirsa; Mark Goodfellow; Christian Meisel; Klaus Lehnertz

doi:10.1016/j.seizure.2020.03.010

Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference

Hitten P. Zaveri, Bjoern Schelter, Catherine A. Schevon, Premysl Jiruska, John G. R. Jefferys, Gregory Worrell, Andreas Schulze-Bonhage, Rasesh B. Joshi, Viktor Jirsa, Mark Goodfellow, Christian Meisel, Klaus Lehnertz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Debates on six controversial topics on the network theory of epilepsy were held during two debate sessions, as part of the International Conference for Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the University of Exeter, UK, September 2-5 2019. The debate topics were (1) From pathologic to physiologic: is the epileptic network part of an existing large-scale brain network? (2) Are micro scale recordings pertinent for defining the epileptic network? (3) From seconds to years: do we need all temporal scales to define an epileptic network? (4) Is it necessary to fully define the epileptic network to control it? (5) Is controlling seizures sufficient to control the epileptic network? (6) Does the epileptic network want to be controlled? This article, written by the organizing committee for the debate sessions and the debaters, summarizes the arguments presented during the debates on these six topics.

Original language	English
Pages (from-to)	78-85
Number of pages	8
Journal	Seizure
Volume	78
Early online date	19 Mar 2020
DOIs	https://doi.org/10.1016/j.seizure.2020.03.010
Publication status	Published - May 2020
Event	International Conference for Technology and Analysis of Seizures, 2019 (ICTALS2019) - University of Exeter, Exeter, United Kingdom Duration: 2 Sept 2019 → 5 Sept 2019

Bibliographical note

Acknowledgements
We would like to acknowledge the contributions of the discussants to the exposition and discussion of the six debate topics. The discussants for debates 1-6 were Fabrice Wendling, Mark Cook, Mark Richardson, Thorsten Rings, Klaus Lehnertz and Piotr Suffczynski, respectively. Funding for ICTALS 2019 was received from the following foundations and industry partners: UCB S.A. (Belgium), American Epilepsy Society (AES), Epilepsy Innovation Institute (Ei2) and Epilepsy Foundation of America (EFA), NeuraLynx (Bozeman, MT, USA) and LivaNova (London, UK). The contribution of HZ was supported by award R01NS109062 from the National Institutes of Health, MG by the EPSRC via grants EP/P021417/1 and EP/N014391/1 and a Wellcome Trust Institutional Strategic Support Award (WT105618MA), and PJ by awards from the Ministry of Health of the Czech Republic AZV 17-28427A and the Czech Science Foundation 20-25298S. The opinions expressed in this article do not necessarily reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.

Keywords

Epileptic network
Ictogenesis
Epileptogenesis
Seizure control
Nodes
Edges
PERFUSION CHANGES
LONG-TERM
HIGH-FREQUENCY OSCILLATIONS
RECURRENT SEIZURES
BRAIN MODELS
EVOLUTION
SEIZURE ONSET ZONE
GLUTAMINE-SYNTHETASE
METHIONINE SULFOXIMINE
FOCAL EPILEPSY

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@article{8bb77b5ec1c54b17902132fc14991a82,

title = "Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference",

abstract = "Debates on six controversial topics on the network theory of epilepsy were held during two debate sessions, as part of the International Conference for Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the University of Exeter, UK, September 2-5 2019. The debate topics were (1) From pathologic to physiologic: is the epileptic network part of an existing large-scale brain network? (2) Are micro scale recordings pertinent for defining the epileptic network? (3) From seconds to years: do we need all temporal scales to define an epileptic network? (4) Is it necessary to fully define the epileptic network to control it? (5) Is controlling seizures sufficient to control the epileptic network? (6) Does the epileptic network want to be controlled? This article, written by the organizing committee for the debate sessions and the debaters, summarizes the arguments presented during the debates on these six topics.",

keywords = "Epileptic network, Ictogenesis, Epileptogenesis, Seizure control, Nodes, Edges, PERFUSION CHANGES, LONG-TERM, HIGH-FREQUENCY OSCILLATIONS, RECURRENT SEIZURES, BRAIN MODELS, EVOLUTION, SEIZURE ONSET ZONE, GLUTAMINE-SYNTHETASE, METHIONINE SULFOXIMINE, FOCAL EPILEPSY",

author = "Zaveri, {Hitten P.} and Bjoern Schelter and Schevon, {Catherine A.} and Premysl Jiruska and Jefferys, {John G. R.} and Gregory Worrell and Andreas Schulze-Bonhage and Joshi, {Rasesh B.} and Viktor Jirsa and Mark Goodfellow and Christian Meisel and Klaus Lehnertz",

note = "Acknowledgements We would like to acknowledge the contributions of the discussants to the exposition and discussion of the six debate topics. The discussants for debates 1-6 were Fabrice Wendling, Mark Cook, Mark Richardson, Thorsten Rings, Klaus Lehnertz and Piotr Suffczynski, respectively. Funding for ICTALS 2019 was received from the following foundations and industry partners: UCB S.A. (Belgium), American Epilepsy Society (AES), Epilepsy Innovation Institute (Ei2) and Epilepsy Foundation of America (EFA), NeuraLynx (Bozeman, MT, USA) and LivaNova (London, UK). The contribution of HZ was supported by award R01NS109062 from the National Institutes of Health, MG by the EPSRC via grants EP/P021417/1 and EP/N014391/1 and a Wellcome Trust Institutional Strategic Support Award (WT105618MA), and PJ by awards from the Ministry of Health of the Czech Republic AZV 17-28427A and the Czech Science Foundation 20-25298S. The opinions expressed in this article do not necessarily reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.; International Conference for Technology and Analysis of Seizures, 2019 (ICTALS2019) ; Conference date: 02-09-2019 Through 05-09-2019",

year = "2020",

month = may,

doi = "10.1016/j.seizure.2020.03.010",

language = "English",

volume = "78",

pages = "78--85",

journal = "Seizure",

issn = "1059-1311",

publisher = "W.B. Saunders Ltd",

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T2 - International Conference for Technology and Analysis of Seizures, 2019 (ICTALS2019)

AU - Zaveri, Hitten P.

AU - Schelter, Bjoern

AU - Schevon, Catherine A.

AU - Jiruska, Premysl

AU - Jefferys, John G. R.

AU - Worrell, Gregory

AU - Schulze-Bonhage, Andreas

AU - Joshi, Rasesh B.

AU - Jirsa, Viktor

AU - Goodfellow, Mark

AU - Meisel, Christian

AU - Lehnertz, Klaus

N1 - Acknowledgements We would like to acknowledge the contributions of the discussants to the exposition and discussion of the six debate topics. The discussants for debates 1-6 were Fabrice Wendling, Mark Cook, Mark Richardson, Thorsten Rings, Klaus Lehnertz and Piotr Suffczynski, respectively. Funding for ICTALS 2019 was received from the following foundations and industry partners: UCB S.A. (Belgium), American Epilepsy Society (AES), Epilepsy Innovation Institute (Ei2) and Epilepsy Foundation of America (EFA), NeuraLynx (Bozeman, MT, USA) and LivaNova (London, UK). The contribution of HZ was supported by award R01NS109062 from the National Institutes of Health, MG by the EPSRC via grants EP/P021417/1 and EP/N014391/1 and a Wellcome Trust Institutional Strategic Support Award (WT105618MA), and PJ by awards from the Ministry of Health of the Czech Republic AZV 17-28427A and the Czech Science Foundation 20-25298S. The opinions expressed in this article do not necessarily reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.

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N2 - Debates on six controversial topics on the network theory of epilepsy were held during two debate sessions, as part of the International Conference for Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the University of Exeter, UK, September 2-5 2019. The debate topics were (1) From pathologic to physiologic: is the epileptic network part of an existing large-scale brain network? (2) Are micro scale recordings pertinent for defining the epileptic network? (3) From seconds to years: do we need all temporal scales to define an epileptic network? (4) Is it necessary to fully define the epileptic network to control it? (5) Is controlling seizures sufficient to control the epileptic network? (6) Does the epileptic network want to be controlled? This article, written by the organizing committee for the debate sessions and the debaters, summarizes the arguments presented during the debates on these six topics.

AB - Debates on six controversial topics on the network theory of epilepsy were held during two debate sessions, as part of the International Conference for Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the University of Exeter, UK, September 2-5 2019. The debate topics were (1) From pathologic to physiologic: is the epileptic network part of an existing large-scale brain network? (2) Are micro scale recordings pertinent for defining the epileptic network? (3) From seconds to years: do we need all temporal scales to define an epileptic network? (4) Is it necessary to fully define the epileptic network to control it? (5) Is controlling seizures sufficient to control the epileptic network? (6) Does the epileptic network want to be controlled? This article, written by the organizing committee for the debate sessions and the debaters, summarizes the arguments presented during the debates on these six topics.

KW - Epileptic network

KW - Ictogenesis

KW - Epileptogenesis

KW - Seizure control

KW - Nodes

KW - Edges

KW - PERFUSION CHANGES

KW - LONG-TERM

KW - HIGH-FREQUENCY OSCILLATIONS

KW - RECURRENT SEIZURES

KW - BRAIN MODELS

KW - EVOLUTION

KW - SEIZURE ONSET ZONE

KW - GLUTAMINE-SYNTHETASE

KW - METHIONINE SULFOXIMINE

KW - FOCAL EPILEPSY

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DO - 10.1016/j.seizure.2020.03.010

M3 - Article

SN - 1059-1311

VL - 78

SP - 78

EP - 85

JO - Seizure

JF - Seizure

Y2 - 2 September 2019 through 5 September 2019

ER -

Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference

Abstract

Bibliographical note

Keywords

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