Coordination and planning of clinical research on a national and global level

Adam J. Devall*, Henk Jan Out, Ben Willem J. Mol, James M.N. Duffy, Barbara Collura, Silke Dyer

*Corresponding author for this work

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

In reproductive medicine, the needs and desires of infertility patients drive future research, with the most important outcome being live birth of a baby. Large, multicenter, randomized clinical trials are considered the best research tool to evaluate the effectiveness of medical interventions, but they can often take a long time to find definitive answers. Advances in individual participant data (IPD) and network meta-analysis have enabled research questions to be answered more quickly, but better planning could streamline this process further. To harmonize research findings that are taking place globally in this way, it is crucial that the same outcomes are collected in clinical trials conducted in reproductive medicine. Furthermore, the conduct of clinical trials often requires collaboration on an international scale; however, individual countries have their own processes for research prioritization and delivery. We describe the perspective of high- and low-resourced settings and industry as well as the mechanisms of prioritization and coordination that are in place in different settings. In addition, we discuss the importance of the patient perspective, which can help shape the research question, clinical trial design, and the logistical operations of trial delivery. The need for increased global collaboration and coalitions within and between stakeholders is evident for the research community to accelerate advances and maximize benefits in reproductive medicine.

Original languageEnglish
Pages (from-to)1100-1106
Number of pages7
JournalFertility and Sterility
Volume113
Issue number6
Early online date30 May 2020
DOIs
Publication statusPublished - Jun 2020

Keywords

  • clinical trials
  • Core outcomes
  • Global South
  • meta-analysis
  • reproductive medicine
  • RANDOMIZED CONTROLLED-TRIALS
  • MULTICENTER
  • FRESH
  • BLIND
  • NONINFERIORITY
  • RECOMBINANT
  • INFERTILITY
  • FOLLICLE-STIMULATING-HORMONE
  • FROZEN EMBRYOS
  • OVARIAN STIMULATION

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