Corneal biomechanical properties in primary open angle glaucoma and normal tension glaucoma

Ghee Soon Ang, Frank Bochmann, John Townend, Augusto Azuara-Blanco

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

PURPOSE: To determine and compare the corneal biomechanical properties between eyes with primary open angle glaucoma (POAG) and eyes with normal tension glaucoma (NTG). PATIENTS AND METHODS: Prospective cross-sectional study. Consecutive eligible POAG and NTG patients attending the Glaucoma Clinic had assessment of their corneal biomechanical properties-corneal hysteresis (CH) and corneal resistance factor (CRF)-using the Ocular Response Analyzer by an observer masked to the diagnosis. Exclusion criteria included previous intraocular surgery, corneal pathology, inflammatory connective tissue disease, and refraction of 5-dimensional or over. If both eyes were eligible, then the right eye was used for analysis. The main outcome measures were corneal hysteresis and CRF measurements. Data analysis was performed using the t test and general linear model. RESULTS: Eighty-one patients (80 whites) were analyzed. Forty had NTG, whereas 41 had POAG. Thirty-five were females. There was a statistically significant difference in mean CH (NTG 9.6+/-1.3 mm Hg; POAG 9.0+/-1.4 mm Hg; P=0.01), but not in mean CRF (NTG 9.9+/-1.4; POAG 10.8+/-1.7; P=0.06). The highest recorded Goldmann applanation intraocular pressure (IOP) was statistically significantly associated with lower CH (P=0.01) and higher CRF (P=0.02). CONCLUSIONS: There was a small but statistically significant difference in the mean CH between POAG and NTG (CH was higher in NTG). The highest recorded Goldmann applanation IOP was also statistically significantly correlated with lower CH and higher CRF, suggesting that alterations to the corneal biomechanical properties may occur as a result of chronic raised IOP in POAG.
Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalJournal of Glaucoma
Volume17
Issue number4
DOIs
Publication statusPublished - Jun 2008

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Low Tension Glaucoma
R Factors
Intraocular Pressure
Connective Tissue Diseases
Primary Open Angle Glaucoma
Glaucoma
Linear Models
Cross-Sectional Studies
Outcome Assessment (Health Care)
Pathology

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomechanics
  • Cornea
  • Cross-Sectional Studies
  • Elastic Tissue
  • Female
  • Glaucoma, Open-Angle
  • Humans
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Prospective Studies
  • Tonometry, Ocular

Cite this

Corneal biomechanical properties in primary open angle glaucoma and normal tension glaucoma. / Ang, Ghee Soon; Bochmann, Frank; Townend, John; Azuara-Blanco, Augusto.

In: Journal of Glaucoma, Vol. 17, No. 4, 06.2008, p. 259-262.

Research output: Contribution to journalArticle

Ang, Ghee Soon ; Bochmann, Frank ; Townend, John ; Azuara-Blanco, Augusto. / Corneal biomechanical properties in primary open angle glaucoma and normal tension glaucoma. In: Journal of Glaucoma. 2008 ; Vol. 17, No. 4. pp. 259-262.
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T1 - Corneal biomechanical properties in primary open angle glaucoma and normal tension glaucoma

AU - Ang, Ghee Soon

AU - Bochmann, Frank

AU - Townend, John

AU - Azuara-Blanco, Augusto

PY - 2008/6

Y1 - 2008/6

N2 - PURPOSE: To determine and compare the corneal biomechanical properties between eyes with primary open angle glaucoma (POAG) and eyes with normal tension glaucoma (NTG). PATIENTS AND METHODS: Prospective cross-sectional study. Consecutive eligible POAG and NTG patients attending the Glaucoma Clinic had assessment of their corneal biomechanical properties-corneal hysteresis (CH) and corneal resistance factor (CRF)-using the Ocular Response Analyzer by an observer masked to the diagnosis. Exclusion criteria included previous intraocular surgery, corneal pathology, inflammatory connective tissue disease, and refraction of 5-dimensional or over. If both eyes were eligible, then the right eye was used for analysis. The main outcome measures were corneal hysteresis and CRF measurements. Data analysis was performed using the t test and general linear model. RESULTS: Eighty-one patients (80 whites) were analyzed. Forty had NTG, whereas 41 had POAG. Thirty-five were females. There was a statistically significant difference in mean CH (NTG 9.6+/-1.3 mm Hg; POAG 9.0+/-1.4 mm Hg; P=0.01), but not in mean CRF (NTG 9.9+/-1.4; POAG 10.8+/-1.7; P=0.06). The highest recorded Goldmann applanation intraocular pressure (IOP) was statistically significantly associated with lower CH (P=0.01) and higher CRF (P=0.02). CONCLUSIONS: There was a small but statistically significant difference in the mean CH between POAG and NTG (CH was higher in NTG). The highest recorded Goldmann applanation IOP was also statistically significantly correlated with lower CH and higher CRF, suggesting that alterations to the corneal biomechanical properties may occur as a result of chronic raised IOP in POAG.

AB - PURPOSE: To determine and compare the corneal biomechanical properties between eyes with primary open angle glaucoma (POAG) and eyes with normal tension glaucoma (NTG). PATIENTS AND METHODS: Prospective cross-sectional study. Consecutive eligible POAG and NTG patients attending the Glaucoma Clinic had assessment of their corneal biomechanical properties-corneal hysteresis (CH) and corneal resistance factor (CRF)-using the Ocular Response Analyzer by an observer masked to the diagnosis. Exclusion criteria included previous intraocular surgery, corneal pathology, inflammatory connective tissue disease, and refraction of 5-dimensional or over. If both eyes were eligible, then the right eye was used for analysis. The main outcome measures were corneal hysteresis and CRF measurements. Data analysis was performed using the t test and general linear model. RESULTS: Eighty-one patients (80 whites) were analyzed. Forty had NTG, whereas 41 had POAG. Thirty-five were females. There was a statistically significant difference in mean CH (NTG 9.6+/-1.3 mm Hg; POAG 9.0+/-1.4 mm Hg; P=0.01), but not in mean CRF (NTG 9.9+/-1.4; POAG 10.8+/-1.7; P=0.06). The highest recorded Goldmann applanation intraocular pressure (IOP) was statistically significantly associated with lower CH (P=0.01) and higher CRF (P=0.02). CONCLUSIONS: There was a small but statistically significant difference in the mean CH between POAG and NTG (CH was higher in NTG). The highest recorded Goldmann applanation IOP was also statistically significantly correlated with lower CH and higher CRF, suggesting that alterations to the corneal biomechanical properties may occur as a result of chronic raised IOP in POAG.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biomechanics

KW - Cornea

KW - Cross-Sectional Studies

KW - Elastic Tissue

KW - Female

KW - Glaucoma, Open-Angle

KW - Humans

KW - Intraocular Pressure

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Tonometry, Ocular

U2 - 10.1097/IJG.0b013e31815c3a93

DO - 10.1097/IJG.0b013e31815c3a93

M3 - Article

VL - 17

SP - 259

EP - 262

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 4

ER -