Background: The treatment of patients with varicose veins constitutes a considerable workload and financial burden to the National Health Service. This study aimed to assess the cost-effectiveness of ultrasound-guided foam sclerotherapy (UGFS) and endovenous laser ablation (EVLA) compared with conventional surgery as treatment for primary varicose veins.
Methods: Participant cost and utility data were collected alongside the UK CLASS multicentre randomized clinical trial, which compared EVLA, surgery and UGFS. Regression methods were used to estimate the effects of the alternative treatments on costs to the health service and quality-adjusted life-years (QALYs) at 6 months. A Markov model, incorporating available evidence on clinical recurrence rates, was developed to extrapolate the trial data over a 5-year time horizon.
Results: Compared with surgery at 6 months, UGFS and EVLA reducedmean costs to the health service by 655 pound and 160 pound respectively. When additional overhead costs associated with theatre use were included, these cost savings increased to 902 pound and 392 pound respectively. UGFS produced 0.005 fewer QALYs, whereas EVLA produced 0.011 additional QALYs. Extrapolating to 5 years, EVLA was associated with increased costs and QALYs compared with UGFS (costing 3640 pound per QALY gained), and generated a cost saving (206-439) pound and QALY gain (0.078) compared with surgery. Applying a ceiling willingness-to-pay ratio of 20 pound 000 per QALY gained, EVLA had the highest probability (78.7 per cent) of being cost-effective.
Conclusion: The results suggest, for patients considered eligible for all three treatment options, that EVLA has the highest probability of being cost-effective at accepted thresholds of willingness to pay per QALY.
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- School of Medicine, Medical Sciences & Nutrition, Health Services Research Unit (HSRU) - Director of Health Services Research Unit
- Institute of Applied Health Sciences
- Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)