Could Helicobacter organisms cause inflammatory bowel disease?

Richard Hansen, John Thomson, James G. Fox, Emad Munir El-Omar, Georgina L. Hold

Research output: Contribution to journalLiterature review

50 Citations (Scopus)

Abstract

Robin Warren and Barry Marshall deservedly won the Nobel Prize for medicine in 2005 for their groundbreaking discovery that Helicobacter pylori was the infectious agent underpinning gastric and duodenal ulceration. This discovery transformed the management of two chronic conditions from maintenance symptomatic therapies, and in some cases surgery, to curative treatment with targeted antibiotics. The possibility that infections by other organisms from the genus Helicobacter are the pathogenic mechanism behind other human diseases is a tantalising one. The inflammatory bowel diseases (IBD): Crohn’s disease (CD) and ulcerative colitis (UC) demonstrate many similarities to gastric and duodenal ulceration before the discovery of H. pylori, including unexplained onset in previously healthy hosts, a chronic disease course with no curative treatments, chronic gastrointestinal inflammation and predisposition to malignant change. In this review article, we shall consider the evidence supporting Helicobacter organisms as pathogenic agents in IBD. We will discuss the relative incompatibility of H. pylori disease and IBD, highlighted by the apparent protective effect of prior H. pylori infection on IBD disease risk. We shall review animal variants of IBD which are both initiated by and associated with Helicobacter infection. We will then review the Helicobacter organisms associated with human gastrointestinal disease and the molecular evidence for Helicobacter organisms in human IBD. For the purpose of clarity, Helicobacter organisms associated primarily with gastritis or biliary disease are not covered within this article.
Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalFEMS Immunology and Medical Microbiology
Volume61
Issue number1
Early online date19 Oct 2010
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Helicobacter
Inflammatory Bowel Diseases
Helicobacter pylori
Helicobacter Infections
Nobel Prize
Gastrointestinal Agents
Songbirds
Gastrointestinal Diseases
Gastritis
Ulcerative Colitis
Crohn Disease
Stomach
Chronic Disease
Maintenance
Medicine
Anti-Bacterial Agents
Inflammation
Infection

Keywords

  • Helicobacter
  • inflammatory bowel disease
  • Crohn's disease
  • ulcerative colitis
  • aetiology
  • microbiota

Cite this

Could Helicobacter organisms cause inflammatory bowel disease? / Hansen, Richard; Thomson, John; Fox, James G.; El-Omar, Emad Munir; Hold, Georgina L.

In: FEMS Immunology and Medical Microbiology, Vol. 61, No. 1, 02.2011, p. 1-14.

Research output: Contribution to journalLiterature review

Hansen, Richard ; Thomson, John ; Fox, James G. ; El-Omar, Emad Munir ; Hold, Georgina L. / Could Helicobacter organisms cause inflammatory bowel disease?. In: FEMS Immunology and Medical Microbiology. 2011 ; Vol. 61, No. 1. pp. 1-14.
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