COX-2 and neurodegeneration in Parkinson's disease

Peter Teismann; M Vila; D-K Choi; K Tieu; D C Wu; V Jackson-Lewis; S Przedborski

doi:10.1111/j.1749-6632.2003.tb07482.x

COX-2 and neurodegeneration in Parkinson's disease

Peter Teismann, M Vila, D-K Choi, K Tieu, D C Wu, V Jackson-Lewis, S Przedborski

Medical Sciences

Research output: Contribution to journal › Article › peer-review

163 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Recent observations link cyclooxygenase type-2 (COX-2) to the progression of the disease. Consistent with this notion, studies with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show that inhibition and ablation of COX-2 markedly reduce the deleterious effects of this toxin on the nigrostriatal pathway. The similarity between this experimental model and PD strongly supports the possibility that COX-2 expression is also pathogenic in PD.

Original language	English
Pages (from-to)	272-277
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	991
DOIs	https://doi.org/10.1111/j.1749-6632.2003.tb07482.x
Publication status	Published - 1 Jun 2003

Keywords

Animals
Anti-Inflammatory Agents
Cyclooxygenase 2
Humans
Isoenzymes
MPTP Poisoning
Membrane Proteins
Mice
Nerve Degeneration
Parkinson Disease
Prostaglandin-Endoperoxide Synthases
Substantia Nigra
Thiazines
Thiazoles
inflammation
neurotoxicity
neurodegeneration
MPTP
Parkinson's disease
reactive oxygen species
superoxide dismutase

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10.1111/j.1749-6632.2003.tb07482.x

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title = "COX-2 and neurodegeneration in Parkinson's disease",

abstract = "Parkinson's disease (PD) is a common neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Recent observations link cyclooxygenase type-2 (COX-2) to the progression of the disease. Consistent with this notion, studies with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show that inhibition and ablation of COX-2 markedly reduce the deleterious effects of this toxin on the nigrostriatal pathway. The similarity between this experimental model and PD strongly supports the possibility that COX-2 expression is also pathogenic in PD.",

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author = "Peter Teismann and M Vila and D-K Choi and K Tieu and Wu, {D C} and V Jackson-Lewis and S Przedborski",

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T1 - COX-2 and neurodegeneration in Parkinson's disease

AU - Teismann, Peter

AU - Vila, M

AU - Choi, D-K

AU - Tieu, K

AU - Wu, D C

AU - Jackson-Lewis, V

AU - Przedborski, S

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Parkinson's disease (PD) is a common neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Recent observations link cyclooxygenase type-2 (COX-2) to the progression of the disease. Consistent with this notion, studies with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show that inhibition and ablation of COX-2 markedly reduce the deleterious effects of this toxin on the nigrostriatal pathway. The similarity between this experimental model and PD strongly supports the possibility that COX-2 expression is also pathogenic in PD.

AB - Parkinson's disease (PD) is a common neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Recent observations link cyclooxygenase type-2 (COX-2) to the progression of the disease. Consistent with this notion, studies with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show that inhibition and ablation of COX-2 markedly reduce the deleterious effects of this toxin on the nigrostriatal pathway. The similarity between this experimental model and PD strongly supports the possibility that COX-2 expression is also pathogenic in PD.

KW - Animals

KW - Anti-Inflammatory Agents

KW - Cyclooxygenase 2

KW - Humans

KW - Isoenzymes

KW - MPTP Poisoning

KW - Membrane Proteins

KW - Mice

KW - Nerve Degeneration

KW - Parkinson Disease

KW - Prostaglandin-Endoperoxide Synthases

KW - Substantia Nigra

KW - Thiazines

KW - Thiazoles

KW - inflammation

KW - neurotoxicity

KW - neurodegeneration

KW - MPTP

KW - Parkinson's disease

KW - reactive oxygen species

KW - superoxide dismutase

U2 - 10.1111/j.1749-6632.2003.tb07482.x

DO - 10.1111/j.1749-6632.2003.tb07482.x

M3 - Article

C2 - 12846993

SN - 0077-8923

VL - 991

SP - 272

EP - 277

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

COX-2 and neurodegeneration in Parkinson's disease

Abstract

Keywords

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