COX-2 and neurodegeneration in Parkinson's disease

Peter Teismann, M Vila, D-K Choi, K Tieu, D C Wu, V Jackson-Lewis, S Przedborski

Research output: Contribution to journalArticle

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Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Recent observations link cyclooxygenase type-2 (COX-2) to the progression of the disease. Consistent with this notion, studies with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show that inhibition and ablation of COX-2 markedly reduce the deleterious effects of this toxin on the nigrostriatal pathway. The similarity between this experimental model and PD strongly supports the possibility that COX-2 expression is also pathogenic in PD.
Original languageEnglish
Pages (from-to)272-277
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume991
DOIs
Publication statusPublished - 1 Jun 2003

Fingerprint

Cyclooxygenase 2
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dopaminergic Neurons
Neurotoxins
Parkinsonian Disorders
Neurodegenerative Diseases
Disease Progression
Theoretical Models
Ablation
Neurons
Parkinson's Disease

Keywords

  • Animals
  • Anti-Inflammatory Agents
  • Cyclooxygenase 2
  • Humans
  • Isoenzymes
  • MPTP Poisoning
  • Membrane Proteins
  • Mice
  • Nerve Degeneration
  • Parkinson Disease
  • Prostaglandin-Endoperoxide Synthases
  • Substantia Nigra
  • Thiazines
  • Thiazoles
  • inflammation
  • neurotoxicity
  • neurodegeneration
  • MPTP
  • Parkinson's disease
  • reactive oxygen species
  • superoxide dismutase

Cite this

Teismann, P., Vila, M., Choi, D-K., Tieu, K., Wu, D. C., Jackson-Lewis, V., & Przedborski, S. (2003). COX-2 and neurodegeneration in Parkinson's disease. Annals of the New York Academy of Sciences, 991, 272-277. https://doi.org/10.1111/j.1749-6632.2003.tb07482.x

COX-2 and neurodegeneration in Parkinson's disease. / Teismann, Peter; Vila, M; Choi, D-K; Tieu, K; Wu, D C; Jackson-Lewis, V; Przedborski, S.

In: Annals of the New York Academy of Sciences, Vol. 991, 01.06.2003, p. 272-277.

Research output: Contribution to journalArticle

Teismann, P, Vila, M, Choi, D-K, Tieu, K, Wu, DC, Jackson-Lewis, V & Przedborski, S 2003, 'COX-2 and neurodegeneration in Parkinson's disease', Annals of the New York Academy of Sciences, vol. 991, pp. 272-277. https://doi.org/10.1111/j.1749-6632.2003.tb07482.x
Teismann P, Vila M, Choi D-K, Tieu K, Wu DC, Jackson-Lewis V et al. COX-2 and neurodegeneration in Parkinson's disease. Annals of the New York Academy of Sciences. 2003 Jun 1;991:272-277. https://doi.org/10.1111/j.1749-6632.2003.tb07482.x
Teismann, Peter ; Vila, M ; Choi, D-K ; Tieu, K ; Wu, D C ; Jackson-Lewis, V ; Przedborski, S. / COX-2 and neurodegeneration in Parkinson's disease. In: Annals of the New York Academy of Sciences. 2003 ; Vol. 991. pp. 272-277.
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