CpG oligodeoxynucleotides up-regulate antibacterial systems and induce protection against bacterial challenge in rainbow trout (Oncorhynchus mykiss)

Allison Christina Carrington, Christopher John Secombes

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The effects of unmethylated CpG oligodeoxynucleotides (ODN) on the mammalian immune system are relatively well studied but much less is known of their effects on the immune systems of different fish species. Here we show that CpG ODNs significantly enhance the survival of rainbow trout (Oncorhynchus mykiss) following bacterial challenge when used both as stand-alone prophylactic agents, or as adjuvants to a commercially available vaccine. They are also capable of increasing serum lysozyme activity in vivo and stimulating the production of chemoattractant factors for rainbow trout head kidney (HK) leucocytes in vitro.

Original languageEnglish
Pages (from-to)781-792
Number of pages12
JournalFish & Shellfish Immunology
Volume23
Issue number4
Early online date7 Mar 2007
DOIs
Publication statusPublished - Oct 2007

Keywords

  • CpG
  • rainbow trout
  • adjuvant
  • bacterial challenge
  • lysozyme
  • chemoattractant
  • salmo-salar l.
  • in-vitro
  • immune-responses
  • peritoneal-cavity
  • cyprinus-carpio
  • DNA
  • motifs
  • macrophages
  • cells
  • activation

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