Creatinine and eGFR are similarly predictive of outcome of acute coronary syndrome

INTRODUCTION: This study aimed to compare the ability of creatinine and estimated glomerular filtration rate (eGFR) to predict outcome in unselected patients with acute coronary syndrome (ACS).

METHODS: Data on renal function at admission and in-hospital outcome were available for 781 of 1165 consecutive admissions with definite or suspected ACS to two Scottish district general hospitals. The c-statistic was used to compare the ability of serum creatinine and eGFR to predict in-hospital death or major acute coronary event (MACE) defined as recurrent myocardial infarction, recurrent ischaemia requiring percutaneous intervention or death.

RESULTS: There were no significant differences between the c-statistic for prediction of death (creatinine 0.76 (95% CI 0.68-0.84), eGFR 0.80 (95% CI 0.73-0.87)) or MACE (creatinine 0.63 (95% CI 0.57-0.69), eGFR 0.61 (95% CI 0.55-0.67)).

CONCLUSION: Creatinine and eGFR are similarly predictive in stratifying risk of mortality and MACE in 'real world' patients with acute coronary syndrome.