Abstract
In this opinion paper the toxicokinetic behaviour of arsenosugars is reviewed and compared with that of inorganic arsenic and arsenobetaine. It is concluded that the arsenosugars are similar to inorganic arsenic in terms of metabolite formation and tissue accumulation. As a pragmatic means of generating uniform data sets which adequately represent the toxicity of arsenic in food we recommend reporting partly speciated arsenic concentrations in food commodities in three fractions: i) toxic inorganic arsenic as arsenate (after oxidation); ii) arsenobetaine as established non-toxic arsenic; and iii) potentially toxic arsenic, which includes arsenosugars and other organoarsenicals.
Original language | English |
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Pages (from-to) | 1735-1741 |
Number of pages | 7 |
Journal | Analytical and Bioanalytical Chemistry |
Volume | 399 |
Issue number | 5 |
Early online date | 23 Oct 2010 |
DOIs | |
Publication status | Published - Feb 2011 |
Keywords
- arsenic
- speciation
- legislation
- food analysis
- metabolism
- accumulation
- HPLC-ICP-MS
- thio-dimethylarsinate
- acute toxicity
- human urine
- sheep
- ingestion
- seaweed
- acid
- arsenobetaine