Critical review or scientific opinion paper

Arsenosugars - a class of benign arsenic species or justification for developing partly speciated arsenic fractionation in foodstuffs?

Jörg Feldmann (Corresponding Author), Eva M. Krupp

Research output: Contribution to journalLiterature review

102 Citations (Scopus)

Abstract

In this opinion paper the toxicokinetic behaviour of arsenosugars is reviewed and compared with that of inorganic arsenic and arsenobetaine. It is concluded that the arsenosugars are similar to inorganic arsenic in terms of metabolite formation and tissue accumulation. As a pragmatic means of generating uniform data sets which adequately represent the toxicity of arsenic in food we recommend reporting partly speciated arsenic concentrations in food commodities in three fractions: i) toxic inorganic arsenic as arsenate (after oxidation); ii) arsenobetaine as established non-toxic arsenic; and iii) potentially toxic arsenic, which includes arsenosugars and other organoarsenicals.

Original languageEnglish
Pages (from-to)1735-1741
Number of pages7
JournalAnalytical and Bioanalytical Chemistry
Volume399
Issue number5
Early online date23 Oct 2010
DOIs
Publication statusPublished - Feb 2011

Keywords

  • arsenic
  • speciation
  • legislation
  • food analysis
  • metabolism
  • accumulation
  • HPLC-ICP-MS
  • thio-dimethylarsinate
  • acute toxicity
  • human urine
  • sheep
  • ingestion
  • seaweed
  • acid
  • arsenobetaine

Cite this

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title = "Critical review or scientific opinion paper: Arsenosugars - a class of benign arsenic species or justification for developing partly speciated arsenic fractionation in foodstuffs?",
abstract = "In this opinion paper the toxicokinetic behaviour of arsenosugars is reviewed and compared with that of inorganic arsenic and arsenobetaine. It is concluded that the arsenosugars are similar to inorganic arsenic in terms of metabolite formation and tissue accumulation. As a pragmatic means of generating uniform data sets which adequately represent the toxicity of arsenic in food we recommend reporting partly speciated arsenic concentrations in food commodities in three fractions: i) toxic inorganic arsenic as arsenate (after oxidation); ii) arsenobetaine as established non-toxic arsenic; and iii) potentially toxic arsenic, which includes arsenosugars and other organoarsenicals.",
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T1 - Critical review or scientific opinion paper

T2 - Arsenosugars - a class of benign arsenic species or justification for developing partly speciated arsenic fractionation in foodstuffs?

AU - Feldmann, Jörg

AU - Krupp, Eva M.

PY - 2011/2

Y1 - 2011/2

N2 - In this opinion paper the toxicokinetic behaviour of arsenosugars is reviewed and compared with that of inorganic arsenic and arsenobetaine. It is concluded that the arsenosugars are similar to inorganic arsenic in terms of metabolite formation and tissue accumulation. As a pragmatic means of generating uniform data sets which adequately represent the toxicity of arsenic in food we recommend reporting partly speciated arsenic concentrations in food commodities in three fractions: i) toxic inorganic arsenic as arsenate (after oxidation); ii) arsenobetaine as established non-toxic arsenic; and iii) potentially toxic arsenic, which includes arsenosugars and other organoarsenicals.

AB - In this opinion paper the toxicokinetic behaviour of arsenosugars is reviewed and compared with that of inorganic arsenic and arsenobetaine. It is concluded that the arsenosugars are similar to inorganic arsenic in terms of metabolite formation and tissue accumulation. As a pragmatic means of generating uniform data sets which adequately represent the toxicity of arsenic in food we recommend reporting partly speciated arsenic concentrations in food commodities in three fractions: i) toxic inorganic arsenic as arsenate (after oxidation); ii) arsenobetaine as established non-toxic arsenic; and iii) potentially toxic arsenic, which includes arsenosugars and other organoarsenicals.

KW - arsenic

KW - speciation

KW - legislation

KW - food analysis

KW - metabolism

KW - accumulation

KW - HPLC-ICP-MS

KW - thio-dimethylarsinate

KW - acute toxicity

KW - human urine

KW - sheep

KW - ingestion

KW - seaweed

KW - acid

KW - arsenobetaine

U2 - 10.1007/s00216-010-4303-6

DO - 10.1007/s00216-010-4303-6

M3 - Literature review

VL - 399

SP - 1735

EP - 1741

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

SN - 1618-2642

IS - 5

ER -