Crosstalk between Wnt and bone morphogenic protein signaling

A turbulent relationship

Nobue Itasaki, Stefan Hoppler

Research output: Contribution to journalLiterature review

91 Citations (Scopus)

Abstract

The Wnt and the bone morphogenic protein (BMP) pathways are evolutionarily conserved and essentially independent signaling mechanisms, which, however, often regulate similar biological processes. Wnt and BMP signaling are functionally integrated in many biological processes, such as embryonic patterning in Drosophila and vertebrates, formation of kidney, limb, teeth and bones, maintenance of stem cells, and cancer progression. Detailed inspection of regulation in these and other tissues reveals that Wnt and BMP signaling are functionally integrated in four fundamentally different ways. The molecular mechanism evolved to mediate this integration can also be summarized in four different ways. However, a fundamental aspect of functional and mechanistic interaction between these pathways relies on tissue-specific mechanisms, which are often not conserved and cannot be extrapolated to other tissues. Integration of the two pathways contributes toward the sophisticated means necessary for creating the complexity of our bodies and the reliable and healthy function of its tissues and organs.
Original languageEnglish
Pages (from-to)16-33
Number of pages18
JournalDevelopmental Dynamics
Volume239
Issue number1
Early online date19 Jun 2009
DOIs
Publication statusPublished - Jan 2010

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Biological Phenomena
Bone and Bones
Proteins
Neoplastic Stem Cells
Drosophila
Vertebrates
Tooth
Extremities
Maintenance
Kidney

Keywords

  • Wnt
  • BMP
  • crosstalk
  • signalling
  • Drosophila
  • vertebrate embryos
  • patterning
  • stem cell
  • organogenesis
  • cancer

Cite this

Crosstalk between Wnt and bone morphogenic protein signaling : A turbulent relationship. / Itasaki, Nobue; Hoppler, Stefan.

In: Developmental Dynamics, Vol. 239, No. 1, 01.2010, p. 16-33.

Research output: Contribution to journalLiterature review

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