CTLA-4 polymorphisms in allergy and asthma and the Th1/Th2 paradigm

M. C. Munthe-Kaas, K. H. Carlsen, Peter Joseph Benedict Helms, J. Gerritsen, W. Whyte, M. Feijen, B. Skinningsrud, Margaret Jessie Campbell Main, G. M. N. Kwong, B. A. Lie, K. C. Lødrup Carlsen, D. E. Undlien

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background: Several genomic regions are reported to be associated with the development of asthma and allergy, including chromosome 2q33. This region harbors the candidate gene cytotoxic T-lymphocyte antigen 4 (CTLA-4), an important regulator of T-cell activation and differentiation.

Objective: We sought to explore possible associations between CTLA-4 polymorphisms and allergy and asthma. Methods: Seven single nucleotide polymorphisms (SNPs; MH30, -1147CT, +49AG, CT60, JO31, JO30, JO27_1) in CTLA-4 were analyzed for associations with total serum IgE, allergic sensitization (positive skin prick test to common allergens), bronchial hyperresponsiveness (BHR) to methacholine, asthma, and lung function (FEV1% of predicted) in 364 asthmatic families from 3 European countries.

Results: Transmission disequilibrium test analysis showed that several SNPs were significantly associated with serum IgE levels, allergy, asthma, and FEV1% predicted below 80%, but not with BHR, and CTLA-4 polymorphisms of potentially direct pathogenic significance in atopic disorders were identified.

Conclusion: We identified associations between 4 newly discovered SNPs in the CTLA-4 gene and serum IgE levels, allergy, asthma, and reduced lung function, but not BHR, suggesting an important role for CTLA-4 in atopy and reduced lung function in asthmatic subjects rather than asthma per se. The particular SNP alleles found positively associated with our phenotypes were recently shown to be associated negatively with autoimmune disorders. Although a skewing toward a T(H)1 reactivity pattern is believed to characterize autoimmune diseases, atopic diseases are considered T(H)2-mediated. Hence, our data suggest a role for CTLA-4 polymorphisms in determining the T(H)1/T(H)2 balance and identify CTLA-4 signaling as a potential therapeutic target in atopic disease.

Original languageEnglish
Pages (from-to)280-287
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume114
DOIs
Publication statusPublished - 2004

Keywords

  • asthma
  • allergy
  • atopy
  • IgE
  • bronchial hyperresponsiveness
  • FEV1
  • genetic analysis
  • CTLA-4 polymorphisms
  • association study
  • GENOME-WIDE SEARCH
  • BRONCHIAL HYPERRESPONSIVENESS
  • DISEQUILIBRIUM TEST
  • IGE LEVELS
  • GENE
  • ASSOCIATION
  • SUSCEPTIBILITY
  • DISEASES
  • DIFFERENTIATION
  • COSTIMULATION

Cite this

Munthe-Kaas, M. C., Carlsen, K. H., Helms, P. J. B., Gerritsen, J., Whyte, W., Feijen, M., ... Undlien, D. E. (2004). CTLA-4 polymorphisms in allergy and asthma and the Th1/Th2 paradigm. Journal of Allergy and Clinical Immunology, 114, 280-287. https://doi.org/10.1016/j.jaci.2004.03.050

CTLA-4 polymorphisms in allergy and asthma and the Th1/Th2 paradigm. / Munthe-Kaas, M. C.; Carlsen, K. H.; Helms, Peter Joseph Benedict; Gerritsen, J.; Whyte, W.; Feijen, M.; Skinningsrud, B.; Main, Margaret Jessie Campbell; Kwong, G. M. N.; Lie, B. A.; Lødrup Carlsen, K. C.; Undlien, D. E.

In: Journal of Allergy and Clinical Immunology, Vol. 114, 2004, p. 280-287.

Research output: Contribution to journalArticle

Munthe-Kaas, MC, Carlsen, KH, Helms, PJB, Gerritsen, J, Whyte, W, Feijen, M, Skinningsrud, B, Main, MJC, Kwong, GMN, Lie, BA, Lødrup Carlsen, KC & Undlien, DE 2004, 'CTLA-4 polymorphisms in allergy and asthma and the Th1/Th2 paradigm', Journal of Allergy and Clinical Immunology, vol. 114, pp. 280-287. https://doi.org/10.1016/j.jaci.2004.03.050
Munthe-Kaas, M. C. ; Carlsen, K. H. ; Helms, Peter Joseph Benedict ; Gerritsen, J. ; Whyte, W. ; Feijen, M. ; Skinningsrud, B. ; Main, Margaret Jessie Campbell ; Kwong, G. M. N. ; Lie, B. A. ; Lødrup Carlsen, K. C. ; Undlien, D. E. / CTLA-4 polymorphisms in allergy and asthma and the Th1/Th2 paradigm. In: Journal of Allergy and Clinical Immunology. 2004 ; Vol. 114. pp. 280-287.
@article{51cfc42b29934dfd914a736be56b1b9e,
title = "CTLA-4 polymorphisms in allergy and asthma and the Th1/Th2 paradigm",
abstract = "Background: Several genomic regions are reported to be associated with the development of asthma and allergy, including chromosome 2q33. This region harbors the candidate gene cytotoxic T-lymphocyte antigen 4 (CTLA-4), an important regulator of T-cell activation and differentiation.Objective: We sought to explore possible associations between CTLA-4 polymorphisms and allergy and asthma. Methods: Seven single nucleotide polymorphisms (SNPs; MH30, -1147CT, +49AG, CT60, JO31, JO30, JO27_1) in CTLA-4 were analyzed for associations with total serum IgE, allergic sensitization (positive skin prick test to common allergens), bronchial hyperresponsiveness (BHR) to methacholine, asthma, and lung function (FEV1{\%} of predicted) in 364 asthmatic families from 3 European countries.Results: Transmission disequilibrium test analysis showed that several SNPs were significantly associated with serum IgE levels, allergy, asthma, and FEV1{\%} predicted below 80{\%}, but not with BHR, and CTLA-4 polymorphisms of potentially direct pathogenic significance in atopic disorders were identified.Conclusion: We identified associations between 4 newly discovered SNPs in the CTLA-4 gene and serum IgE levels, allergy, asthma, and reduced lung function, but not BHR, suggesting an important role for CTLA-4 in atopy and reduced lung function in asthmatic subjects rather than asthma per se. The particular SNP alleles found positively associated with our phenotypes were recently shown to be associated negatively with autoimmune disorders. Although a skewing toward a T(H)1 reactivity pattern is believed to characterize autoimmune diseases, atopic diseases are considered T(H)2-mediated. Hence, our data suggest a role for CTLA-4 polymorphisms in determining the T(H)1/T(H)2 balance and identify CTLA-4 signaling as a potential therapeutic target in atopic disease.",
keywords = "asthma, allergy, atopy, IgE, bronchial hyperresponsiveness, FEV1, genetic analysis, CTLA-4 polymorphisms, association study, GENOME-WIDE SEARCH, BRONCHIAL HYPERRESPONSIVENESS, DISEQUILIBRIUM TEST, IGE LEVELS, GENE, ASSOCIATION, SUSCEPTIBILITY, DISEASES, DIFFERENTIATION, COSTIMULATION",
author = "Munthe-Kaas, {M. C.} and Carlsen, {K. H.} and Helms, {Peter Joseph Benedict} and J. Gerritsen and W. Whyte and M. Feijen and B. Skinningsrud and Main, {Margaret Jessie Campbell} and Kwong, {G. M. N.} and Lie, {B. A.} and {L{\o}drup Carlsen}, {K. C.} and Undlien, {D. E.}",
year = "2004",
doi = "10.1016/j.jaci.2004.03.050",
language = "English",
volume = "114",
pages = "280--287",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby/Elsevier,",

}

TY - JOUR

T1 - CTLA-4 polymorphisms in allergy and asthma and the Th1/Th2 paradigm

AU - Munthe-Kaas, M. C.

AU - Carlsen, K. H.

AU - Helms, Peter Joseph Benedict

AU - Gerritsen, J.

AU - Whyte, W.

AU - Feijen, M.

AU - Skinningsrud, B.

AU - Main, Margaret Jessie Campbell

AU - Kwong, G. M. N.

AU - Lie, B. A.

AU - Lødrup Carlsen, K. C.

AU - Undlien, D. E.

PY - 2004

Y1 - 2004

N2 - Background: Several genomic regions are reported to be associated with the development of asthma and allergy, including chromosome 2q33. This region harbors the candidate gene cytotoxic T-lymphocyte antigen 4 (CTLA-4), an important regulator of T-cell activation and differentiation.Objective: We sought to explore possible associations between CTLA-4 polymorphisms and allergy and asthma. Methods: Seven single nucleotide polymorphisms (SNPs; MH30, -1147CT, +49AG, CT60, JO31, JO30, JO27_1) in CTLA-4 were analyzed for associations with total serum IgE, allergic sensitization (positive skin prick test to common allergens), bronchial hyperresponsiveness (BHR) to methacholine, asthma, and lung function (FEV1% of predicted) in 364 asthmatic families from 3 European countries.Results: Transmission disequilibrium test analysis showed that several SNPs were significantly associated with serum IgE levels, allergy, asthma, and FEV1% predicted below 80%, but not with BHR, and CTLA-4 polymorphisms of potentially direct pathogenic significance in atopic disorders were identified.Conclusion: We identified associations between 4 newly discovered SNPs in the CTLA-4 gene and serum IgE levels, allergy, asthma, and reduced lung function, but not BHR, suggesting an important role for CTLA-4 in atopy and reduced lung function in asthmatic subjects rather than asthma per se. The particular SNP alleles found positively associated with our phenotypes were recently shown to be associated negatively with autoimmune disorders. Although a skewing toward a T(H)1 reactivity pattern is believed to characterize autoimmune diseases, atopic diseases are considered T(H)2-mediated. Hence, our data suggest a role for CTLA-4 polymorphisms in determining the T(H)1/T(H)2 balance and identify CTLA-4 signaling as a potential therapeutic target in atopic disease.

AB - Background: Several genomic regions are reported to be associated with the development of asthma and allergy, including chromosome 2q33. This region harbors the candidate gene cytotoxic T-lymphocyte antigen 4 (CTLA-4), an important regulator of T-cell activation and differentiation.Objective: We sought to explore possible associations between CTLA-4 polymorphisms and allergy and asthma. Methods: Seven single nucleotide polymorphisms (SNPs; MH30, -1147CT, +49AG, CT60, JO31, JO30, JO27_1) in CTLA-4 were analyzed for associations with total serum IgE, allergic sensitization (positive skin prick test to common allergens), bronchial hyperresponsiveness (BHR) to methacholine, asthma, and lung function (FEV1% of predicted) in 364 asthmatic families from 3 European countries.Results: Transmission disequilibrium test analysis showed that several SNPs were significantly associated with serum IgE levels, allergy, asthma, and FEV1% predicted below 80%, but not with BHR, and CTLA-4 polymorphisms of potentially direct pathogenic significance in atopic disorders were identified.Conclusion: We identified associations between 4 newly discovered SNPs in the CTLA-4 gene and serum IgE levels, allergy, asthma, and reduced lung function, but not BHR, suggesting an important role for CTLA-4 in atopy and reduced lung function in asthmatic subjects rather than asthma per se. The particular SNP alleles found positively associated with our phenotypes were recently shown to be associated negatively with autoimmune disorders. Although a skewing toward a T(H)1 reactivity pattern is believed to characterize autoimmune diseases, atopic diseases are considered T(H)2-mediated. Hence, our data suggest a role for CTLA-4 polymorphisms in determining the T(H)1/T(H)2 balance and identify CTLA-4 signaling as a potential therapeutic target in atopic disease.

KW - asthma

KW - allergy

KW - atopy

KW - IgE

KW - bronchial hyperresponsiveness

KW - FEV1

KW - genetic analysis

KW - CTLA-4 polymorphisms

KW - association study

KW - GENOME-WIDE SEARCH

KW - BRONCHIAL HYPERRESPONSIVENESS

KW - DISEQUILIBRIUM TEST

KW - IGE LEVELS

KW - GENE

KW - ASSOCIATION

KW - SUSCEPTIBILITY

KW - DISEASES

KW - DIFFERENTIATION

KW - COSTIMULATION

U2 - 10.1016/j.jaci.2004.03.050

DO - 10.1016/j.jaci.2004.03.050

M3 - Article

VL - 114

SP - 280

EP - 287

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

ER -