Cultivable bacterial diversity from the human colon

Research output: Contribution to journalLiterature review

121 Citations (Scopus)

Abstract

Knowledge of the composition of the colonic microbiota is important for our understanding of how the balance of these microbes is influenced by diet and the environment, and which bacterial groups are important in maintaining gut health or promoting disease. Molecular methodologies have advanced our understanding of the composition and diversity of the colonic microbiota. Importantly, however, it is the continued isolation of bacterial representatives of key groups that offers the best opportunity to conduct detailed metabolic and functional studies. This also permits bacterial genome sequencing which will accelerate the linkage to functionality. Obtaining new human colonic bacterial isolates can be challenging, because most of these are strict anaerobes and many have rather exact nutritional and physical requirements. Despite this many new species are being isolated and described that occupy distinct niches in the colonic microbial community. This review focuses on these under-studied yet important gut anaerobes.

Original languageEnglish
Pages (from-to)343-350
Number of pages8
JournalLetters in Applied Microbiology
Volume44
Issue number4
Early online date12 Mar 2007
DOIs
Publication statusPublished - Apr 2007

Keywords

  • anaerobes
  • colonic microbiota
  • human health
  • Roseburia
  • human large-intestine
  • human fecal sample
  • SP-NOV.
  • human feces
  • GEN.-NOV.
  • human gut
  • roseburia-inulinivorans
  • butyrate
  • fermentation
  • bacteroides

Cite this

Cultivable bacterial diversity from the human colon. / Duncan, Sylvia Helen; Louis, Petra; Flint, Harry James.

In: Letters in Applied Microbiology, Vol. 44, No. 4, 04.2007, p. 343-350.

Research output: Contribution to journalLiterature review

@article{a704d80bf85340e68c910fe2fe518b03,
title = "Cultivable bacterial diversity from the human colon",
abstract = "Knowledge of the composition of the colonic microbiota is important for our understanding of how the balance of these microbes is influenced by diet and the environment, and which bacterial groups are important in maintaining gut health or promoting disease. Molecular methodologies have advanced our understanding of the composition and diversity of the colonic microbiota. Importantly, however, it is the continued isolation of bacterial representatives of key groups that offers the best opportunity to conduct detailed metabolic and functional studies. This also permits bacterial genome sequencing which will accelerate the linkage to functionality. Obtaining new human colonic bacterial isolates can be challenging, because most of these are strict anaerobes and many have rather exact nutritional and physical requirements. Despite this many new species are being isolated and described that occupy distinct niches in the colonic microbial community. This review focuses on these under-studied yet important gut anaerobes.",
keywords = "anaerobes, colonic microbiota, human health, Roseburia, human large-intestine, human fecal sample, SP-NOV., human feces, GEN.-NOV., human gut, roseburia-inulinivorans, butyrate, fermentation, bacteroides",
author = "Duncan, {Sylvia Helen} and Petra Louis and Flint, {Harry James}",
year = "2007",
month = "4",
doi = "10.1111/j.1472-765X.2007.02129.x",
language = "English",
volume = "44",
pages = "343--350",
journal = "Letters in Applied Microbiology",
issn = "0266-8254",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Cultivable bacterial diversity from the human colon

AU - Duncan, Sylvia Helen

AU - Louis, Petra

AU - Flint, Harry James

PY - 2007/4

Y1 - 2007/4

N2 - Knowledge of the composition of the colonic microbiota is important for our understanding of how the balance of these microbes is influenced by diet and the environment, and which bacterial groups are important in maintaining gut health or promoting disease. Molecular methodologies have advanced our understanding of the composition and diversity of the colonic microbiota. Importantly, however, it is the continued isolation of bacterial representatives of key groups that offers the best opportunity to conduct detailed metabolic and functional studies. This also permits bacterial genome sequencing which will accelerate the linkage to functionality. Obtaining new human colonic bacterial isolates can be challenging, because most of these are strict anaerobes and many have rather exact nutritional and physical requirements. Despite this many new species are being isolated and described that occupy distinct niches in the colonic microbial community. This review focuses on these under-studied yet important gut anaerobes.

AB - Knowledge of the composition of the colonic microbiota is important for our understanding of how the balance of these microbes is influenced by diet and the environment, and which bacterial groups are important in maintaining gut health or promoting disease. Molecular methodologies have advanced our understanding of the composition and diversity of the colonic microbiota. Importantly, however, it is the continued isolation of bacterial representatives of key groups that offers the best opportunity to conduct detailed metabolic and functional studies. This also permits bacterial genome sequencing which will accelerate the linkage to functionality. Obtaining new human colonic bacterial isolates can be challenging, because most of these are strict anaerobes and many have rather exact nutritional and physical requirements. Despite this many new species are being isolated and described that occupy distinct niches in the colonic microbial community. This review focuses on these under-studied yet important gut anaerobes.

KW - anaerobes

KW - colonic microbiota

KW - human health

KW - Roseburia

KW - human large-intestine

KW - human fecal sample

KW - SP-NOV.

KW - human feces

KW - GEN.-NOV.

KW - human gut

KW - roseburia-inulinivorans

KW - butyrate

KW - fermentation

KW - bacteroides

U2 - 10.1111/j.1472-765X.2007.02129.x

DO - 10.1111/j.1472-765X.2007.02129.x

M3 - Literature review

VL - 44

SP - 343

EP - 350

JO - Letters in Applied Microbiology

JF - Letters in Applied Microbiology

SN - 0266-8254

IS - 4

ER -