Current concepts in tumour-derived organoids

Ross John Porter, Graeme Murray, Mairi H McLean* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Cancer comprises a collection of highly proliferative and heterogeneous cells growing within an adaptive and evolving tumour microenvironment. Cancer survival rates have significantly improved following decades of cancer research. However, many experimental and preclinical studies do not translate to the bedside, reflecting the challenges of modelling the complexities and multicellular basis of human disease. Organoids are novel, complex, three dimensional ex vivo tissue cultures that are derived from embryonic stem cells, induced
pluripotent stem cells or tissue resident progenitor cells, and represent a near-physiological
model for studying cancer. Organoids develop by self-organisation and can accurately
represent the diverse genetic, cellular and pathophysiological hallmarks of cancer. In addition, co-culture methods and the ability to genetically manipulate these organoids have widened their utility in cancer research. Organoids thus offer a new and exciting platform
for studying cancer and directing personalised therapies. This review aims to highlight how organoids are shaping the future of cancer research.
Original languageEnglish
Number of pages10
JournalBritish Journal of Cancer
Early online date30 Jul 2020
DOIs
Publication statusE-pub ahead of print - 30 Jul 2020

Keywords

  • COLORECTAL-CANCER
  • MOUSE MODELS
  • INTESTINAL ORGANOIDS
  • EPITHELIAL ORGANOIDS
  • XENOGRAFT MODELS
  • HUMAN COLON
  • IN-VITRO
  • TRANSPLANTATION
  • CELLS
  • MICE

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