Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes

T O Nashar, T Amin, A Marcello, T R Hirst

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The development of non-living carrier systems for delivery of protective antigens or epitopes to the immune system represents both a fundamental and an applied aspect of vaccinology. A wide range of carrier systems, ranging from inert supports to proteins that exert direct immunomodulating effects on the immune response, are being studied. In this overview we describe the current progress in the development of the B-subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as potential protein carriers for the oral delivery of chemically and genetically attached antigens and epitopes.

Original languageEnglish
Pages (from-to)235-40
Number of pages6
JournalVaccine
Volume11
Issue number2
Publication statusPublished - 1993

Fingerprint

Heterophile Antigens
cholera toxin
Cholera
Enterotoxins
enterotoxins
epitopes
Epitopes
mouth
Escherichia coli
antigens
heat
Antigens
transport proteins
vaccine development
immune system
Immune System
Carrier Proteins
immune response
Proteins
proteins

Keywords

  • Adjuvants, Immunologic
  • Administration, Oral
  • Amino Acid Sequence
  • Animals
  • Antibody Formation
  • Antigens
  • Bacterial Toxins
  • Cholera Toxin
  • Drug Carriers
  • Enterotoxins
  • Epitopes
  • Escherichia coli
  • Escherichia coli Proteins
  • Hemocyanin
  • Mice
  • Mice, Inbred Strains
  • Models, Molecular
  • Molecular Sequence Data
  • Recombinant Fusion Proteins
  • Vaccines
  • Vaccines, Synthetic
  • Vibrio cholerae

Cite this

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title = "Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes",
abstract = "The development of non-living carrier systems for delivery of protective antigens or epitopes to the immune system represents both a fundamental and an applied aspect of vaccinology. A wide range of carrier systems, ranging from inert supports to proteins that exert direct immunomodulating effects on the immune response, are being studied. In this overview we describe the current progress in the development of the B-subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as potential protein carriers for the oral delivery of chemically and genetically attached antigens and epitopes.",
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author = "Nashar, {T O} and T Amin and A Marcello and Hirst, {T R}",
year = "1993",
language = "English",
volume = "11",
pages = "235--40",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "2",

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TY - JOUR

T1 - Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes

AU - Nashar, T O

AU - Amin, T

AU - Marcello, A

AU - Hirst, T R

PY - 1993

Y1 - 1993

N2 - The development of non-living carrier systems for delivery of protective antigens or epitopes to the immune system represents both a fundamental and an applied aspect of vaccinology. A wide range of carrier systems, ranging from inert supports to proteins that exert direct immunomodulating effects on the immune response, are being studied. In this overview we describe the current progress in the development of the B-subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as potential protein carriers for the oral delivery of chemically and genetically attached antigens and epitopes.

AB - The development of non-living carrier systems for delivery of protective antigens or epitopes to the immune system represents both a fundamental and an applied aspect of vaccinology. A wide range of carrier systems, ranging from inert supports to proteins that exert direct immunomodulating effects on the immune response, are being studied. In this overview we describe the current progress in the development of the B-subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as potential protein carriers for the oral delivery of chemically and genetically attached antigens and epitopes.

KW - Adjuvants, Immunologic

KW - Administration, Oral

KW - Amino Acid Sequence

KW - Animals

KW - Antibody Formation

KW - Antigens

KW - Bacterial Toxins

KW - Cholera Toxin

KW - Drug Carriers

KW - Enterotoxins

KW - Epitopes

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - Hemocyanin

KW - Mice

KW - Mice, Inbred Strains

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Recombinant Fusion Proteins

KW - Vaccines

KW - Vaccines, Synthetic

KW - Vibrio cholerae

M3 - Article

VL - 11

SP - 235

EP - 240

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 2

ER -