Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes

T O Nashar; T Amin; A Marcello; T R Hirst

Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes

T O Nashar, T Amin, A Marcello, T R Hirst

Medical Sciences

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

The development of non-living carrier systems for delivery of protective antigens or epitopes to the immune system represents both a fundamental and an applied aspect of vaccinology. A wide range of carrier systems, ranging from inert supports to proteins that exert direct immunomodulating effects on the immune response, are being studied. In this overview we describe the current progress in the development of the B-subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as potential protein carriers for the oral delivery of chemically and genetically attached antigens and epitopes.

Original language	English
Pages (from-to)	235-40
Number of pages	6
Journal	Vaccine
Volume	11
Issue number	2
Publication status	Published - 1993

Keywords

Adjuvants, Immunologic
Administration, Oral
Amino Acid Sequence
Animals
Antibody Formation
Antigens
Bacterial Toxins
Cholera Toxin
Drug Carriers
Enterotoxins
Epitopes
Escherichia coli
Escherichia coli Proteins
Hemocyanin
Mice
Mice, Inbred Strains
Models, Molecular
Molecular Sequence Data
Recombinant Fusion Proteins
Vaccines
Vaccines, Synthetic
Vibrio cholerae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes",

abstract = "The development of non-living carrier systems for delivery of protective antigens or epitopes to the immune system represents both a fundamental and an applied aspect of vaccinology. A wide range of carrier systems, ranging from inert supports to proteins that exert direct immunomodulating effects on the immune response, are being studied. In this overview we describe the current progress in the development of the B-subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as potential protein carriers for the oral delivery of chemically and genetically attached antigens and epitopes.",

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author = "Nashar, {T O} and T Amin and A Marcello and Hirst, {T R}",

year = "1993",

language = "English",

volume = "11",

pages = "235--40",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes

AU - Nashar, T O

AU - Amin, T

AU - Marcello, A

AU - Hirst, T R

PY - 1993

Y1 - 1993

N2 - The development of non-living carrier systems for delivery of protective antigens or epitopes to the immune system represents both a fundamental and an applied aspect of vaccinology. A wide range of carrier systems, ranging from inert supports to proteins that exert direct immunomodulating effects on the immune response, are being studied. In this overview we describe the current progress in the development of the B-subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as potential protein carriers for the oral delivery of chemically and genetically attached antigens and epitopes.

AB - The development of non-living carrier systems for delivery of protective antigens or epitopes to the immune system represents both a fundamental and an applied aspect of vaccinology. A wide range of carrier systems, ranging from inert supports to proteins that exert direct immunomodulating effects on the immune response, are being studied. In this overview we describe the current progress in the development of the B-subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as potential protein carriers for the oral delivery of chemically and genetically attached antigens and epitopes.

KW - Adjuvants, Immunologic

KW - Administration, Oral

KW - Amino Acid Sequence

KW - Animals

KW - Antibody Formation

KW - Antigens

KW - Bacterial Toxins

KW - Cholera Toxin

KW - Drug Carriers

KW - Enterotoxins

KW - Epitopes

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - Hemocyanin

KW - Mice

KW - Mice, Inbred Strains

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Recombinant Fusion Proteins

KW - Vaccines

KW - Vaccines, Synthetic

KW - Vibrio cholerae

M3 - Article

C2 - 7679865

SN - 0264-410X

VL - 11

SP - 235

EP - 240

JO - Vaccine

JF - Vaccine

IS - 2

ER -

Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes

Abstract

Keywords

UN SDGs

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