Cutting DNA: mechanics of the topoisomerase

J M T Thompson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Taking the accurate theoretical solutions of Coleman and Swigon for a DNA plasmid in a plectonemic state under imposed link and responsive writhe, we examine in detail the working of the two types of cutting enzyme (topoisomerase Type 1 and topoisomerase Type 2). The mechanical processes involved can generate a plethora of outcomes, all assigning different levels of relaxation to the molecule. Alternative outcomes arise when there are co-existing (meta-) stable equilibrium states. Resolution of the outcome would then require a dynamic analysis of the relaxation process, though the Maxwell criterion can offer some guidance.
Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalThe European Physical Journal. Special Topics
Volume165
Issue number1
DOIs
Publication statusPublished - Dec 2008

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Type I DNA Topoisomerase
Relaxation processes
Dynamic analysis
Mechanics
Plasmids
DNA
Enzymes
deoxyribonucleic acid
Molecules
plasmids
enzymes
molecules

Cite this

Cutting DNA : mechanics of the topoisomerase. / Thompson, J M T.

In: The European Physical Journal. Special Topics, Vol. 165, No. 1, 12.2008, p. 175-182.

Research output: Contribution to journalArticle

Thompson, J M T. / Cutting DNA : mechanics of the topoisomerase. In: The European Physical Journal. Special Topics. 2008 ; Vol. 165, No. 1. pp. 175-182.
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