Cyclosporin A prevents sensitization after blood transfusion in multiparous rats

M C JONES, D A POWER, Keith Nicol Stewart, G R D CATTO

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1. Humoral immune responses to allogeneic blood transfusions and semi-allogeneic pregnancies were monitored by the indirect haemagglutination assay in strains of inbred rats. 2. Similar titres and ranges of cross-reactive alloantibodies were induced by blood transfusions and pregnancy; the maternal alloantibody response to paternal antigens was not increased by an unrelated antigenic stimulus. 3. Immunosuppression with cyclosporin A was effective in preventing the primary humoral immune response produced by blood transfusion but not in abrogating the established immune response to previous pregnancy. 4. These studies have established an animal model of sensitization that both stimulates the clinical situation of many potential renal transplant recipients and permits analyses of the different antigenic stimuli involved.
Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalClinical Science
Volume74
Issue number4
Publication statusPublished - 1988

Cite this

JONES, M. C., POWER, D. A., Stewart, K. N., & CATTO, G. R. D. (1988). Cyclosporin A prevents sensitization after blood transfusion in multiparous rats. Clinical Science, 74(4), 389-392.

Cyclosporin A prevents sensitization after blood transfusion in multiparous rats. / JONES, M C ; POWER, D A ; Stewart, Keith Nicol; CATTO, G R D .

In: Clinical Science, Vol. 74, No. 4, 1988, p. 389-392.

Research output: Contribution to journalArticle

JONES, MC, POWER, DA, Stewart, KN & CATTO, GRD 1988, 'Cyclosporin A prevents sensitization after blood transfusion in multiparous rats', Clinical Science, vol. 74, no. 4, pp. 389-392.
JONES MC, POWER DA, Stewart KN, CATTO GRD. Cyclosporin A prevents sensitization after blood transfusion in multiparous rats. Clinical Science. 1988;74(4):389-392.
JONES, M C ; POWER, D A ; Stewart, Keith Nicol ; CATTO, G R D . / Cyclosporin A prevents sensitization after blood transfusion in multiparous rats. In: Clinical Science. 1988 ; Vol. 74, No. 4. pp. 389-392.
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N2 - 1. Humoral immune responses to allogeneic blood transfusions and semi-allogeneic pregnancies were monitored by the indirect haemagglutination assay in strains of inbred rats. 2. Similar titres and ranges of cross-reactive alloantibodies were induced by blood transfusions and pregnancy; the maternal alloantibody response to paternal antigens was not increased by an unrelated antigenic stimulus. 3. Immunosuppression with cyclosporin A was effective in preventing the primary humoral immune response produced by blood transfusion but not in abrogating the established immune response to previous pregnancy. 4. These studies have established an animal model of sensitization that both stimulates the clinical situation of many potential renal transplant recipients and permits analyses of the different antigenic stimuli involved.

AB - 1. Humoral immune responses to allogeneic blood transfusions and semi-allogeneic pregnancies were monitored by the indirect haemagglutination assay in strains of inbred rats. 2. Similar titres and ranges of cross-reactive alloantibodies were induced by blood transfusions and pregnancy; the maternal alloantibody response to paternal antigens was not increased by an unrelated antigenic stimulus. 3. Immunosuppression with cyclosporin A was effective in preventing the primary humoral immune response produced by blood transfusion but not in abrogating the established immune response to previous pregnancy. 4. These studies have established an animal model of sensitization that both stimulates the clinical situation of many potential renal transplant recipients and permits analyses of the different antigenic stimuli involved.

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