Cytochrome P450 enzymes: novel options for cancer therapeutics

Morag Catherine Elliott McFadyen, William Thomas Melvin, Graeme Ian Murray

Research output: Contribution to journalEditorial

174 Citations (Scopus)

Abstract

The concept of overexpression of individual forms of cytochrome P450 enzymes in tumor cells is now becoming well recognized. Indeed, a growing body of research highlights the overexpression of P450s, particularly CYP1B1, in tumor cells as representing novel targets for anticancer therapy. The purpose of this review is to outline the novel therapeutic options and opportunities arising from both enhanced endogenous expression of cytochrome P450 in tumors and cytochrome P450-mediated gene therapy.

Original languageEnglish
Pages (from-to)363-371
Number of pages8
JournalMolecular Cancer Therapeutics
Volume3
Issue number3
Publication statusPublished - 2004

Keywords

  • INDOLE ALKALOID BIOSYNTHESIS
  • BREAST-CANCER
  • IN-VITRO
  • ANTICANCER AGENT
  • PRIMARY CULTURES
  • DRUG-METABOLISM
  • RETINOIC ACID
  • GENE-THERAPY
  • CELL-LINES
  • TAXOL BIOSYNTHESIS

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