TY - JOUR
T1 - Cytokine and growth factor profiling in patients with the metabolic syndrome
AU - Mirhafez, Seyed Reza
AU - Pasdar, Alireza
AU - Avan, Amir
AU - Esmaily, Habibollah
AU - Moezzi, Atefeh
AU - Mohebati, Mohsen
AU - Meshkat, Zahra
AU - Mehrad-Majd, Hassan
AU - Eslami, Saied
AU - Rahimi, Hamid Reza
AU - Ghazavi, Hamed
AU - Ferns, Gordon A.
AU - Ghayour-Mobarhan, Majid
N1 - Acknowledgements
We would like to thank all the patients for their help and participating in the study.
This work was supported by the grant from MUMS, Research Council (M. G.-M., S. R. M., A. A. and A. P.). The results obtained in the present study are part of Mr Seyed Reza Mirhafez's PhD thesis (ID no. 910823) in MUMS. MUMS had no role in the design, analysis or writing of this article.
The authors' contributions are as follows: M. G.-M., A. P. and Z. M. contributed to the study design; S. R. M., M. M. and A. R. H.-B. conducted the experimental part; S. R. M., M. G.-M., H. R. R., S. E., H. M.-M., H. E. and A. M. contributed to the data analysis; S. R. M., A. P., A. A., G. A. F., A. P. and M. G.-M. contributed to the preparation of the manuscript.
The authors have no conflict of interest.
PY - 2015/6/28
Y1 - 2015/6/28
N2 - The metabolic syndrome (MetS) is associated with a pro-inflammatory milieu that may partially account for its association with an increased cardiovascular risk. We aimed to (1) evaluate the serum concentrations of twelve cytokines and growth factors (epidermal growth factor (EGF), interferon-γ (IFN-γ), IL-1α/-1β/-2/-4/-6/-8/-10, monocyte chemoattractant protein-1 (MCP-1), TNF-α and vascular endothelial growth factor (VEGF)) in 303 individuals with or without the MetS; and (2) explore their relationship with the presence of the MetS. Patients with the MetS had significantly higher serum concentrations of IFN-γ, EGF, IL-1α/-1β/-2/-4/-6/-8/-10, MCP-1 and TNF-α, whilst serum VEGF concentrations were markedly lower compared with the control group (e.g. 38-55 v. 82-18 pg/ml; P<0-05). Amongst these parameters, IFN-γ and IL-1α emerged as the most significant independent predictors of the MetS. In conclusion, our findings demonstrate that patients with the MetS had an altered blood cytokine and growth factor profile that may partially account for its adverse clinical outcomes. Further prospective studies in larger multi-centre settings are required to unravel the role and association of the emerging biomarkers with the MetS and their implication in therapeutic intervention.
AB - The metabolic syndrome (MetS) is associated with a pro-inflammatory milieu that may partially account for its association with an increased cardiovascular risk. We aimed to (1) evaluate the serum concentrations of twelve cytokines and growth factors (epidermal growth factor (EGF), interferon-γ (IFN-γ), IL-1α/-1β/-2/-4/-6/-8/-10, monocyte chemoattractant protein-1 (MCP-1), TNF-α and vascular endothelial growth factor (VEGF)) in 303 individuals with or without the MetS; and (2) explore their relationship with the presence of the MetS. Patients with the MetS had significantly higher serum concentrations of IFN-γ, EGF, IL-1α/-1β/-2/-4/-6/-8/-10, MCP-1 and TNF-α, whilst serum VEGF concentrations were markedly lower compared with the control group (e.g. 38-55 v. 82-18 pg/ml; P<0-05). Amongst these parameters, IFN-γ and IL-1α emerged as the most significant independent predictors of the MetS. In conclusion, our findings demonstrate that patients with the MetS had an altered blood cytokine and growth factor profile that may partially account for its adverse clinical outcomes. Further prospective studies in larger multi-centre settings are required to unravel the role and association of the emerging biomarkers with the MetS and their implication in therapeutic intervention.
KW - Cytokines
KW - Diabetes
KW - Growth factors
KW - Inflammation
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=84936891331&partnerID=8YFLogxK
U2 - 10.1017/S0007114515001038
DO - 10.1017/S0007114515001038
M3 - Article
C2 - 25990566
AN - SCOPUS:84936891331
VL - 113
SP - 1911
EP - 1919
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 12
ER -
