Cytokine profile of Armenian patients with Familial Mediterranean fever

G. P. Manukyan, K. A. Ghazaryan, Zh. A. Ktsoyall, M. V. Tatyan, Z. A. Khachatryan, G. S. Hakobyan, V. A. Mkrtchyan, Denise Kelly, Alistair George P Coutts, Rustam Irekovitch Aminov

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Abstract

Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.

Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).

Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.

Conclusions: Inflammation in FNIF involves Treg and Th17 lineages. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)920-922
Number of pages3
JournalClinical Biochemistry
Volume41
Issue number10-11
Early online date11 Apr 2008
DOIs
Publication statusPublished - Jul 2008

Keywords

  • familial Mediterranean fever
  • sera
  • ELISA
  • CBA
  • cytokines
  • pyrin
  • activation
  • caspase-1
  • cells
  • Familial Mediterranean fever
  • Sera
  • Cytokines

Cite this

Manukyan, G. P., Ghazaryan, K. A., Ktsoyall, Z. A., Tatyan, M. V., Khachatryan, Z. A., Hakobyan, G. S., Mkrtchyan, V. A., Kelly, D., Coutts, A. G. P., & Aminov, R. I. (2008). Cytokine profile of Armenian patients with Familial Mediterranean fever. Clinical Biochemistry, 41(10-11), 920-922. https://doi.org/10.1016/j.clinbiochem.2008.03.017