Cytokine profile of Armenian patients with Familial Mediterranean fever

G. P. Manukyan, K. A. Ghazaryan, Zh. A. Ktsoyall, M. V. Tatyan, Z. A. Khachatryan, G. S. Hakobyan, V. A. Mkrtchyan, Denise Kelly, Alistair George P Coutts, Rustam Irekovitch Aminov

Research output: Contribution to journalArticle

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Abstract

Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.

Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).

Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.

Conclusions: Inflammation in FNIF involves Treg and Th17 lineages. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)920-922
Number of pages3
JournalClinical Biochemistry
Volume41
Issue number10-11
Early online date11 Apr 2008
DOIs
Publication statusPublished - Jul 2008

Keywords

  • familial Mediterranean fever
  • sera
  • ELISA
  • CBA
  • cytokines
  • pyrin
  • activation
  • caspase-1
  • cells
  • Familial Mediterranean fever
  • Sera
  • Cytokines

Cite this

Manukyan, G. P., Ghazaryan, K. A., Ktsoyall, Z. A., Tatyan, M. V., Khachatryan, Z. A., Hakobyan, G. S., ... Aminov, R. I. (2008). Cytokine profile of Armenian patients with Familial Mediterranean fever. Clinical Biochemistry, 41(10-11), 920-922. https://doi.org/10.1016/j.clinbiochem.2008.03.017

Cytokine profile of Armenian patients with Familial Mediterranean fever. / Manukyan, G. P.; Ghazaryan, K. A.; Ktsoyall, Zh. A.; Tatyan, M. V.; Khachatryan, Z. A.; Hakobyan, G. S.; Mkrtchyan, V. A.; Kelly, Denise; Coutts, Alistair George P; Aminov, Rustam Irekovitch.

In: Clinical Biochemistry, Vol. 41, No. 10-11, 07.2008, p. 920-922.

Research output: Contribution to journalArticle

Manukyan, GP, Ghazaryan, KA, Ktsoyall, ZA, Tatyan, MV, Khachatryan, ZA, Hakobyan, GS, Mkrtchyan, VA, Kelly, D, Coutts, AGP & Aminov, RI 2008, 'Cytokine profile of Armenian patients with Familial Mediterranean fever', Clinical Biochemistry, vol. 41, no. 10-11, pp. 920-922. https://doi.org/10.1016/j.clinbiochem.2008.03.017
Manukyan GP, Ghazaryan KA, Ktsoyall ZA, Tatyan MV, Khachatryan ZA, Hakobyan GS et al. Cytokine profile of Armenian patients with Familial Mediterranean fever. Clinical Biochemistry. 2008 Jul;41(10-11):920-922. https://doi.org/10.1016/j.clinbiochem.2008.03.017
Manukyan, G. P. ; Ghazaryan, K. A. ; Ktsoyall, Zh. A. ; Tatyan, M. V. ; Khachatryan, Z. A. ; Hakobyan, G. S. ; Mkrtchyan, V. A. ; Kelly, Denise ; Coutts, Alistair George P ; Aminov, Rustam Irekovitch. / Cytokine profile of Armenian patients with Familial Mediterranean fever. In: Clinical Biochemistry. 2008 ; Vol. 41, No. 10-11. pp. 920-922.
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AU - Manukyan, G. P.

AU - Ghazaryan, K. A.

AU - Ktsoyall, Zh. A.

AU - Tatyan, M. V.

AU - Khachatryan, Z. A.

AU - Hakobyan, G. S.

AU - Mkrtchyan, V. A.

AU - Kelly, Denise

AU - Coutts, Alistair George P

AU - Aminov, Rustam Irekovitch

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AB - Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.Conclusions: Inflammation in FNIF involves Treg and Th17 lineages. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

KW - familial Mediterranean fever

KW - sera

KW - ELISA

KW - CBA

KW - cytokines

KW - pyrin

KW - activation

KW - caspase-1

KW - cells

KW - Familial Mediterranean fever

KW - Sera

KW - Cytokines

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