Abstract
Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.
Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).
Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.
Conclusions: Inflammation in FNIF involves Treg and Th17 lineages. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Original language | English |
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Pages (from-to) | 920-922 |
Number of pages | 3 |
Journal | Clinical Biochemistry |
Volume | 41 |
Issue number | 10-11 |
Early online date | 11 Apr 2008 |
DOIs | |
Publication status | Published - Jul 2008 |
Keywords
- familial Mediterranean fever
- sera
- ELISA
- CBA
- cytokines
- pyrin
- activation
- caspase-1
- cells
- Familial Mediterranean fever
- Sera
- Cytokines