Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.
Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).
Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.
Conclusions: Inflammation in FNIF involves Treg and Th17 lineages. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
- familial Mediterranean fever
- Familial Mediterranean fever