Cytokines

Heather M Wilson, Robert N Barker

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cytokines are small secreted ‘messenger proteins’ that allow communication between cells. They contribute to a chemical signalling language that controls many processes in multicellular organisms including haematopoiesis, chemoattraction, tissue repair, embryogenesis and virtually all aspects of immunity and inflammation. Cytokine functions are mediated by their binding to specific receptors to initiate intracellular signalling cascades that increase or decrease expression of transcription factors and genes regulating, for example, secretion of effector molecules (including other cytokines), cell proliferation and expression of membrane receptors. They play an important role in many pathologies and indeed measurement of cytokine profiles in patients provides a useful indicator of disease. Due to their multiple functions in disease, therapeutic interference of cytokines, cytokine receptors and their signal transduction pathways offer new treatment options for a range of disorders.
Original languageEnglish
Title of host publicationEncyclopedia of Life Sciences
Place of PublicationChichester, United Kingdom
PublisherJohn Wiley & Sons
ISBN (Electronic)978-0470015902
ISBN (Print)0470066512, 978-0470066515
DOIs
Publication statusPublished - 30 Mar 2007

Publication series

NameEncyclopedia of Life Sciences
PublisherJohn Wiley & Sons

Fingerprint

Cytokines
Cytokine Receptors
Hematopoiesis
Cell Communication
Embryonic Development
Immunity
Signal Transduction
Transcription Factors
Language
Cell Proliferation
Pathology
Inflammation
Membranes
Therapeutics
Genes
Proteins

Cite this

Wilson, H. M., & Barker, R. N. (2007). Cytokines. In Encyclopedia of Life Sciences (Encyclopedia of Life Sciences). Chichester, United Kingdom: John Wiley & Sons. https://doi.org/10.1002/9780470015902.a0000929.pub2

Cytokines. / Wilson, Heather M; Barker, Robert N.

Encyclopedia of Life Sciences. Chichester, United Kingdom : John Wiley & Sons, 2007. (Encyclopedia of Life Sciences).

Research output: Chapter in Book/Report/Conference proceedingChapter

Wilson, HM & Barker, RN 2007, Cytokines. in Encyclopedia of Life Sciences. Encyclopedia of Life Sciences, John Wiley & Sons, Chichester, United Kingdom. https://doi.org/10.1002/9780470015902.a0000929.pub2
Wilson HM, Barker RN. Cytokines. In Encyclopedia of Life Sciences. Chichester, United Kingdom: John Wiley & Sons. 2007. (Encyclopedia of Life Sciences). https://doi.org/10.1002/9780470015902.a0000929.pub2
Wilson, Heather M ; Barker, Robert N. / Cytokines. Encyclopedia of Life Sciences. Chichester, United Kingdom : John Wiley & Sons, 2007. (Encyclopedia of Life Sciences).
@inbook{d9f42fd35bb0444785b26d1c3bbf737d,
title = "Cytokines",
abstract = "Cytokines are small secreted ‘messenger proteins’ that allow communication between cells. They contribute to a chemical signalling language that controls many processes in multicellular organisms including haematopoiesis, chemoattraction, tissue repair, embryogenesis and virtually all aspects of immunity and inflammation. Cytokine functions are mediated by their binding to specific receptors to initiate intracellular signalling cascades that increase or decrease expression of transcription factors and genes regulating, for example, secretion of effector molecules (including other cytokines), cell proliferation and expression of membrane receptors. They play an important role in many pathologies and indeed measurement of cytokine profiles in patients provides a useful indicator of disease. Due to their multiple functions in disease, therapeutic interference of cytokines, cytokine receptors and their signal transduction pathways offer new treatment options for a range of disorders.",
author = "Wilson, {Heather M} and Barker, {Robert N}",
year = "2007",
month = "3",
day = "30",
doi = "10.1002/9780470015902.a0000929.pub2",
language = "English",
isbn = "0470066512",
series = "Encyclopedia of Life Sciences",
publisher = "John Wiley & Sons",
booktitle = "Encyclopedia of Life Sciences",

}

TY - CHAP

T1 - Cytokines

AU - Wilson, Heather M

AU - Barker, Robert N

PY - 2007/3/30

Y1 - 2007/3/30

N2 - Cytokines are small secreted ‘messenger proteins’ that allow communication between cells. They contribute to a chemical signalling language that controls many processes in multicellular organisms including haematopoiesis, chemoattraction, tissue repair, embryogenesis and virtually all aspects of immunity and inflammation. Cytokine functions are mediated by their binding to specific receptors to initiate intracellular signalling cascades that increase or decrease expression of transcription factors and genes regulating, for example, secretion of effector molecules (including other cytokines), cell proliferation and expression of membrane receptors. They play an important role in many pathologies and indeed measurement of cytokine profiles in patients provides a useful indicator of disease. Due to their multiple functions in disease, therapeutic interference of cytokines, cytokine receptors and their signal transduction pathways offer new treatment options for a range of disorders.

AB - Cytokines are small secreted ‘messenger proteins’ that allow communication between cells. They contribute to a chemical signalling language that controls many processes in multicellular organisms including haematopoiesis, chemoattraction, tissue repair, embryogenesis and virtually all aspects of immunity and inflammation. Cytokine functions are mediated by their binding to specific receptors to initiate intracellular signalling cascades that increase or decrease expression of transcription factors and genes regulating, for example, secretion of effector molecules (including other cytokines), cell proliferation and expression of membrane receptors. They play an important role in many pathologies and indeed measurement of cytokine profiles in patients provides a useful indicator of disease. Due to their multiple functions in disease, therapeutic interference of cytokines, cytokine receptors and their signal transduction pathways offer new treatment options for a range of disorders.

U2 - 10.1002/9780470015902.a0000929.pub2

DO - 10.1002/9780470015902.a0000929.pub2

M3 - Chapter

SN - 0470066512

SN - 978-0470066515

T3 - Encyclopedia of Life Sciences

BT - Encyclopedia of Life Sciences

PB - John Wiley & Sons

CY - Chichester, United Kingdom

ER -