Cytotoxic chemotherapy before and after radiotherapy compared with radiotherapy followed by chemotherapy in the treatment of small-cell carcinoma of the bronchus

The results up to 36 months

Report to the medical research council by its lung cancer working party on the third small-cell study

Research output: Contribution to journalArticle

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Abstract

This report compares the results up to 36 months of two sequences of radiotherapy and chemotherapy for small-cell anaplastic carcinoma of the bronchus, of limited extent (defined below). A total of 91 patients were allocated at random to treatment with radiotherapy to the primary site followed by 10 pulses of chemotherapy using cyclophosphamide, methotrexate and CCNU (RC), and 95 to two pulses of the same chemotherapy, followed by radiotherapy, followed by 8 pulses of chemotherapy (CRC). The median survival times were 36 weeks for the RC series and 45 weeks for the CRC series but there was no statistically significant difference in survival (P = 0.9, log-rank test). At 12 months, 32 (35%) of the RC and 38 (40%) of the CRC patients were alive, at 24 months, 8 (9%) and 4 (4%), and at 36 months, 7 (8%) and 1 (1%) respectively. The patients' general condition, grade of activity and respiratory assessment correlated significantly with survival. Of 38 patients reported to be in "excellent" condition at the start of treatment, 6 (16%) were alive at 3 years. Although there was evidence that the onset of metastases was slightly delayed in the CRC series, this difference had disappeared by 12 months.

Original languageEnglish
Pages (from-to)755-761
Number of pages7
JournalBritish Journal of Cancer
Volume48
Issue number6
DOIs
Publication statusPublished - 1 Jan 1983

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Small Cell Carcinoma
Bronchi
Radiotherapy
Drug Therapy
Survival
Lomustine
Therapeutics
Methotrexate
Cyclophosphamide
Neoplasm Metastasis
Carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Cytotoxic chemotherapy before and after radiotherapy compared with radiotherapy followed by chemotherapy in the treatment of small-cell carcinoma of the bronchus : The results up to 36 months. / Report to the medical research council by its lung cancer working party on the third small-cell study.

In: British Journal of Cancer, Vol. 48, No. 6, 01.01.1983, p. 755-761.

Research output: Contribution to journalArticle

Report to the medical research council by its lung cancer working party on the third small-cell study. / Cytotoxic chemotherapy before and after radiotherapy compared with radiotherapy followed by chemotherapy in the treatment of small-cell carcinoma of the bronchus : The results up to 36 months. In: British Journal of Cancer. 1983 ; Vol. 48, No. 6. pp. 755-761.
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abstract = "This report compares the results up to 36 months of two sequences of radiotherapy and chemotherapy for small-cell anaplastic carcinoma of the bronchus, of limited extent (defined below). A total of 91 patients were allocated at random to treatment with radiotherapy to the primary site followed by 10 pulses of chemotherapy using cyclophosphamide, methotrexate and CCNU (RC), and 95 to two pulses of the same chemotherapy, followed by radiotherapy, followed by 8 pulses of chemotherapy (CRC). The median survival times were 36 weeks for the RC series and 45 weeks for the CRC series but there was no statistically significant difference in survival (P = 0.9, log-rank test). At 12 months, 32 (35{\%}) of the RC and 38 (40{\%}) of the CRC patients were alive, at 24 months, 8 (9{\%}) and 4 (4{\%}), and at 36 months, 7 (8{\%}) and 1 (1{\%}) respectively. The patients' general condition, grade of activity and respiratory assessment correlated significantly with survival. Of 38 patients reported to be in {"}excellent{"} condition at the start of treatment, 6 (16{\%}) were alive at 3 years. Although there was evidence that the onset of metastases was slightly delayed in the CRC series, this difference had disappeared by 12 months.",
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