Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

Giovanni Appendino, Gabriella Aviello, Mauro Ballero, Francesca Borrelli, Ernesto Fattorusso, Francesca Petrucci, Federico U Santelia, Orazio Taglialatela-Scafati

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.

Original languageEnglish
Pages (from-to)853-857
Number of pages5
JournalJournal of Natural Products
Volume68
Issue number6
DOIs
Publication statusPublished - Jun 2005

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Germacrane Sesquiterpenes
Human Activities
Colon
Cells
Nuclear magnetic resonance
Antennas
Carcinoma
Cell Line

Keywords

  • Antineoplastic Agents, Phytogenic
  • Asteraceae
  • Drug Screening Assays, Antitumor
  • Humans
  • Italy
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal
  • Sesquiterpenes, Germacrane
  • Stereoisomerism
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Appendino, G., Aviello, G., Ballero, M., Borrelli, F., Fattorusso, E., Petrucci, F., ... Taglialatela-Scafati, O. (2005). Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis. Journal of Natural Products, 68(6), 853-857. https://doi.org/10.1021/np050120q

Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis. / Appendino, Giovanni; Aviello, Gabriella; Ballero, Mauro; Borrelli, Francesca; Fattorusso, Ernesto; Petrucci, Francesca; Santelia, Federico U; Taglialatela-Scafati, Orazio.

In: Journal of Natural Products, Vol. 68, No. 6, 06.2005, p. 853-857.

Research output: Contribution to journalArticle

Appendino, G, Aviello, G, Ballero, M, Borrelli, F, Fattorusso, E, Petrucci, F, Santelia, FU & Taglialatela-Scafati, O 2005, 'Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis', Journal of Natural Products, vol. 68, no. 6, pp. 853-857. https://doi.org/10.1021/np050120q
Appendino G, Aviello G, Ballero M, Borrelli F, Fattorusso E, Petrucci F et al. Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis. Journal of Natural Products. 2005 Jun;68(6):853-857. https://doi.org/10.1021/np050120q
Appendino, Giovanni ; Aviello, Gabriella ; Ballero, Mauro ; Borrelli, Francesca ; Fattorusso, Ernesto ; Petrucci, Francesca ; Santelia, Federico U ; Taglialatela-Scafati, Orazio. / Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis. In: Journal of Natural Products. 2005 ; Vol. 68, No. 6. pp. 853-857.
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