Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

Giovanni Appendino, Gabriella Aviello, Mauro Ballero, Francesca Borrelli, Ernesto Fattorusso, Francesca Petrucci, Federico U Santelia, Orazio Taglialatela-Scafati

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.

Original languageEnglish
Pages (from-to)853-857
Number of pages5
JournalJournal of Natural Products
Volume68
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Antineoplastic Agents, Phytogenic
  • Asteraceae
  • Drug Screening Assays, Antitumor
  • Humans
  • Italy
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal
  • Sesquiterpenes, Germacrane
  • Stereoisomerism
  • Journal Article
  • Research Support, Non-U.S. Gov't

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  • Cite this

    Appendino, G., Aviello, G., Ballero, M., Borrelli, F., Fattorusso, E., Petrucci, F., Santelia, F. U., & Taglialatela-Scafati, O. (2005). Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis. Journal of Natural Products, 68(6), 853-857. https://doi.org/10.1021/np050120q