Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

Giovanni Appendino; Gabriella Aviello; Mauro Ballero; Francesca Borrelli; Ernesto Fattorusso; Francesca Petrucci; Federico U Santelia; Orazio Taglialatela-Scafati

doi:10.1021/np050120q

Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

Giovanni Appendino, Gabriella Aviello, Mauro Ballero, Francesca Borrelli, Ernesto Fattorusso, Francesca Petrucci, Federico U Santelia, Orazio Taglialatela-Scafati

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.

Original language	English
Pages (from-to)	853-857
Number of pages	5
Journal	Journal of Natural Products
Volume	68
Issue number	6
DOIs	https://doi.org/10.1021/np050120q
Publication status	Published - Jun 2005

Keywords

Antineoplastic Agents, Phytogenic
Asteraceae
Drug Screening Assays, Antitumor
Humans
Italy
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plants, Medicinal
Sesquiterpenes, Germacrane
Stereoisomerism
Journal Article
Research Support, Non-U.S. Gov't

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title = "Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis",

abstract = "Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.",

keywords = "Antineoplastic Agents, Phytogenic, Asteraceae, Drug Screening Assays, Antitumor, Humans, Italy, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plants, Medicinal, Sesquiterpenes, Germacrane, Stereoisomerism, Journal Article, Research Support, Non-U.S. Gov't",

author = "Giovanni Appendino and Gabriella Aviello and Mauro Ballero and Francesca Borrelli and Ernesto Fattorusso and Francesca Petrucci and Santelia, {Federico U} and Orazio Taglialatela-Scafati",

year = "2005",

month = jun,

doi = "10.1021/np050120q",

language = "English",

volume = "68",

pages = "853--857",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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T1 - Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

AU - Appendino, Giovanni

AU - Aviello, Gabriella

AU - Ballero, Mauro

AU - Borrelli, Francesca

AU - Fattorusso, Ernesto

AU - Petrucci, Francesca

AU - Santelia, Federico U

AU - Taglialatela-Scafati, Orazio

PY - 2005/6

Y1 - 2005/6

N2 - Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.

AB - Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.

KW - Antineoplastic Agents, Phytogenic

KW - Asteraceae

KW - Drug Screening Assays, Antitumor

KW - Humans

KW - Italy

KW - Molecular Structure

KW - Nuclear Magnetic Resonance, Biomolecular

KW - Plants, Medicinal

KW - Sesquiterpenes, Germacrane

KW - Stereoisomerism

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1021/np050120q

DO - 10.1021/np050120q

M3 - Article

C2 - 15974607

VL - 68

SP - 853

EP - 857

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 6

ER -

Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

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Keywords

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