Cytotoxic T-lymphocyte therapy for post-transplant lymphoproliferative disorder after solid organ transplantation in children

Fang Kuan Chiou, Sue V Beath, Gwen M. Wilkie, Mark A Vickers, Girish L. Gupte

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

EBV-CTL immunotherapy targets EBV antigens expressed by tumor cells in PTLD. Data on outcome of EBV-CTL in pSOT patients are limited. The aim of the study is to describe our experience with allogeneic, third-party EBV-CTL for the treatment of PTLD in pSOT patients in a single tertiary center. Retrospective review was performed of all pSOT patients who received EBV-CTL for PTLD. PTLD was diagnosed using World Health Organization histologic criteria. EBV-CTLs were derived from human leukocyte antigen-typed, EBV-seropositive third-party donors, and cryopreserved and maintained by an accredited national blood transfusion service. Ten patients received EBV-CTL for histologically proven PTLD from 1999 to 2016 following liver (n=5), combined intestinal/liver (n=4), and liver/kidney (n=1) transplantation. PTLD occurred at median age of 40 months (range: 12-144) and median post-transplant interval of 8 months (range: 2-107). Seven had monomorphic, two had polymorphic, and one had Hodgkin-type PTLD. All were of B-cell origin and EBV-positive on histology. EBV-CTL achieved an overall remission rate of 80% (8 of 10). Transient adverse effects included fever, tachycardia, and vomiting. None developed graft-versus-host disease or opportunistic infections. EBV-CTL is an effective treatment for PTLD in pSOT patients, with good remission rate and minimal toxicity.
Original languageEnglish
Article number13133
JournalPediatric Transplantation
Volume22
Issue number2
Early online date1 Feb 2018
DOIs
Publication statusPublished - 31 Mar 2018

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Lymphoproliferative Disorders
Cytotoxic T-Lymphocytes
Organ Transplantation
Human Herpesvirus 4
Transplants
Therapeutics
Liver
Opportunistic Infections
Neoplasm Antigens
Graft vs Host Disease
HLA Antigens
Hodgkin Disease
Tachycardia
Blood Transfusion
Immunotherapy
Vomiting
Histology
B-Lymphocytes
Fever
Transplantation

Keywords

  • adoptive cellular immunotherapy
  • EBV
  • lymphoproliferative disorder
  • organ transplantation

Cite this

Cytotoxic T-lymphocyte therapy for post-transplant lymphoproliferative disorder after solid organ transplantation in children. / Chiou, Fang Kuan; Beath, Sue V; Wilkie, Gwen M.; Vickers, Mark A; Gupte, Girish L.

In: Pediatric Transplantation, Vol. 22, No. 2, 13133, 31.03.2018.

Research output: Contribution to journalArticle

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