Data linkage for pharmacovigilance

attitudes of the public and health professionals

CHIMES

Research output: Contribution to conferencePoster

Abstract

Aim
Children are often subject to off-label prescribing (1,2), i.e. prescribing of a medicine outwith its summary of product characteristics. This is often necessary as children are not routinely participants in clinical trials and the dosage tested in those trials is aimed at adults. As part of the CHIMES project we aim to gather the opinion of health professionals as well as children and their parents/guardians to the linkage of routinely collected paediatric data for Pharmacovigilance purposes in Scotland to tailor solutions to address those concerns before the database is created.
Methodology
This is a mixed qualitative study involving interviews with national key stakeholders, separate focus groups with health professionals and children and parents/guardians as well as a postal survey for the public and a Delphi survey for health professionals.
Outcomes/Results
Preliminary findings from the early interviews (n=14) with key stakeholders (health professionals) have shown that current schemes are perceived as being limited. The creation of the proposed database has raised concerns about data linkage at practical, legal and ethical levels.
For the public involvement study, a pilot interview has been conducted that corroborates concerns with data protection, consent, confidentiality and ownership (of health data) as previously identified in the literature.
Conclusion
The creation of a linked database for pharmacovigilance in children is seen as beneficial and long overdue but several concerns on a practical, legal and ethical level will have to be addressed prior to linking NHS data routinely at a national level.
References
(1) Ekins-Daukes S, Helms P, Simpson CR, Taylor MW, McLay J. Off-label prescribing to children in primary care: retrospective observational study. Eur J Clin Pharmacol 2004;60:349-353.
(2) McIntyre J, Conroy S, Avery A, Corns H, Choonara I. Unlicensed and off label prescribing of drugs in general practice. Arch.Dis.Child. 2000 December 1;83(6):498-501.

Original languageEnglish
Publication statusPublished - 2010
EventNHSScotland Event - Edinburgh, United Kingdom
Duration: 7 Jun 20108 Jun 2010

Conference

ConferenceNHSScotland Event
CountryUnited Kingdom
CityEdinburgh
Period7/06/108/06/10

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Pharmacovigilance
Information Storage and Retrieval
Off-Label Use
Public Health
Databases
Interviews
Health
Callosities
Parents
Computer Security
Ownership
Confidentiality
Scotland
Health Surveys
Focus Groups
General Practice
Observational Studies
Primary Health Care
Retrospective Studies
Medicine

Cite this

CHIMES (2010). Data linkage for pharmacovigilance: attitudes of the public and health professionals. Poster session presented at NHSScotland Event, Edinburgh, United Kingdom.

Data linkage for pharmacovigilance : attitudes of the public and health professionals. / CHIMES.

2010. Poster session presented at NHSScotland Event, Edinburgh, United Kingdom.

Research output: Contribution to conferencePoster

CHIMES 2010, 'Data linkage for pharmacovigilance: attitudes of the public and health professionals' NHSScotland Event, Edinburgh, United Kingdom, 7/06/10 - 8/06/10, .
CHIMES. Data linkage for pharmacovigilance: attitudes of the public and health professionals. 2010. Poster session presented at NHSScotland Event, Edinburgh, United Kingdom.
CHIMES. / Data linkage for pharmacovigilance : attitudes of the public and health professionals. Poster session presented at NHSScotland Event, Edinburgh, United Kingdom.
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title = "Data linkage for pharmacovigilance: attitudes of the public and health professionals",
abstract = "Aim Children are often subject to off-label prescribing (1,2), i.e. prescribing of a medicine outwith its summary of product characteristics. This is often necessary as children are not routinely participants in clinical trials and the dosage tested in those trials is aimed at adults. As part of the CHIMES project we aim to gather the opinion of health professionals as well as children and their parents/guardians to the linkage of routinely collected paediatric data for Pharmacovigilance purposes in Scotland to tailor solutions to address those concerns before the database is created. Methodology This is a mixed qualitative study involving interviews with national key stakeholders, separate focus groups with health professionals and children and parents/guardians as well as a postal survey for the public and a Delphi survey for health professionals. Outcomes/Results Preliminary findings from the early interviews (n=14) with key stakeholders (health professionals) have shown that current schemes are perceived as being limited. The creation of the proposed database has raised concerns about data linkage at practical, legal and ethical levels. For the public involvement study, a pilot interview has been conducted that corroborates concerns with data protection, consent, confidentiality and ownership (of health data) as previously identified in the literature. Conclusion The creation of a linked database for pharmacovigilance in children is seen as beneficial and long overdue but several concerns on a practical, legal and ethical level will have to be addressed prior to linking NHS data routinely at a national level. References (1) Ekins-Daukes S, Helms P, Simpson CR, Taylor MW, McLay J. Off-label prescribing to children in primary care: retrospective observational study. Eur J Clin Pharmacol 2004;60:349-353. (2) McIntyre J, Conroy S, Avery A, Corns H, Choonara I. Unlicensed and off label prescribing of drugs in general practice. Arch.Dis.Child. 2000 December 1;83(6):498-501.",
author = "Yvonne Hopf and Emma Scobie-Scott and Bond, {Christine M} and John Haughney and David Shaw and Helms, {Peter J} and CHIMES",
year = "2010",
language = "English",
note = "NHSScotland Event ; Conference date: 07-06-2010 Through 08-06-2010",

}

TY - CONF

T1 - Data linkage for pharmacovigilance

T2 - attitudes of the public and health professionals

AU - Hopf, Yvonne

AU - Scobie-Scott, Emma

AU - Bond, Christine M

AU - Haughney, John

AU - Shaw, David

AU - Helms, Peter J

AU - CHIMES

PY - 2010

Y1 - 2010

N2 - Aim Children are often subject to off-label prescribing (1,2), i.e. prescribing of a medicine outwith its summary of product characteristics. This is often necessary as children are not routinely participants in clinical trials and the dosage tested in those trials is aimed at adults. As part of the CHIMES project we aim to gather the opinion of health professionals as well as children and their parents/guardians to the linkage of routinely collected paediatric data for Pharmacovigilance purposes in Scotland to tailor solutions to address those concerns before the database is created. Methodology This is a mixed qualitative study involving interviews with national key stakeholders, separate focus groups with health professionals and children and parents/guardians as well as a postal survey for the public and a Delphi survey for health professionals. Outcomes/Results Preliminary findings from the early interviews (n=14) with key stakeholders (health professionals) have shown that current schemes are perceived as being limited. The creation of the proposed database has raised concerns about data linkage at practical, legal and ethical levels. For the public involvement study, a pilot interview has been conducted that corroborates concerns with data protection, consent, confidentiality and ownership (of health data) as previously identified in the literature. Conclusion The creation of a linked database for pharmacovigilance in children is seen as beneficial and long overdue but several concerns on a practical, legal and ethical level will have to be addressed prior to linking NHS data routinely at a national level. References (1) Ekins-Daukes S, Helms P, Simpson CR, Taylor MW, McLay J. Off-label prescribing to children in primary care: retrospective observational study. Eur J Clin Pharmacol 2004;60:349-353. (2) McIntyre J, Conroy S, Avery A, Corns H, Choonara I. Unlicensed and off label prescribing of drugs in general practice. Arch.Dis.Child. 2000 December 1;83(6):498-501.

AB - Aim Children are often subject to off-label prescribing (1,2), i.e. prescribing of a medicine outwith its summary of product characteristics. This is often necessary as children are not routinely participants in clinical trials and the dosage tested in those trials is aimed at adults. As part of the CHIMES project we aim to gather the opinion of health professionals as well as children and their parents/guardians to the linkage of routinely collected paediatric data for Pharmacovigilance purposes in Scotland to tailor solutions to address those concerns before the database is created. Methodology This is a mixed qualitative study involving interviews with national key stakeholders, separate focus groups with health professionals and children and parents/guardians as well as a postal survey for the public and a Delphi survey for health professionals. Outcomes/Results Preliminary findings from the early interviews (n=14) with key stakeholders (health professionals) have shown that current schemes are perceived as being limited. The creation of the proposed database has raised concerns about data linkage at practical, legal and ethical levels. For the public involvement study, a pilot interview has been conducted that corroborates concerns with data protection, consent, confidentiality and ownership (of health data) as previously identified in the literature. Conclusion The creation of a linked database for pharmacovigilance in children is seen as beneficial and long overdue but several concerns on a practical, legal and ethical level will have to be addressed prior to linking NHS data routinely at a national level. References (1) Ekins-Daukes S, Helms P, Simpson CR, Taylor MW, McLay J. Off-label prescribing to children in primary care: retrospective observational study. Eur J Clin Pharmacol 2004;60:349-353. (2) McIntyre J, Conroy S, Avery A, Corns H, Choonara I. Unlicensed and off label prescribing of drugs in general practice. Arch.Dis.Child. 2000 December 1;83(6):498-501.

M3 - Poster

ER -