Deceiving proteins! A case of lymphoma and high creatinine

El Hakem Abdelkarim Metraiah (Corresponding Author), Helen Regan, Johanna Louw, Dana Kidder

Research output: Contribution to journalArticle

4 Downloads (Pure)

Abstract

Estimation of kidney function by measuring serum creatinine is one the commonest laboratory tests conducted in clinical practice. Enzymatic methods are often used to measure serum creatinine. Clinicians should be aware of the limitations of these methods, such as test interference with paraproteins.We present a case of falsely elevated serum creatinine in a patient referred for renal biopsy. The combination of fluctuating creatinine and normal blood urea level was unusual. Serum protein electrophoresis revealed the presence of an IgM paraprotein. Further investigations confirmed an underlying diagnosis of lymphoplasmacytoid lymphoma. This case highlights how IgM paraprotein can interfere with creatinine estimation by enzymatic assay and the utility of alternative methods of estimating serum creatinine.
Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalBMJ Case Reports
Volume2017
DOIs
Publication statusPublished - 23 Jan 2017

Fingerprint

Lymphoma
Creatinine
Paraproteins
Proteins
Serum
Immunoglobulin M
Kidney
Waldenstrom Macroglobulinemia
Enzyme Assays
Urea
Electrophoresis
Blood Proteins
Biopsy

Cite this

Deceiving proteins! A case of lymphoma and high creatinine. / Metraiah, El Hakem Abdelkarim (Corresponding Author); Regan, Helen; Louw, Johanna; Kidder, Dana.

In: BMJ Case Reports, Vol. 2017, 23.01.2017, p. 1-3.

Research output: Contribution to journalArticle

Metraiah, El Hakem Abdelkarim ; Regan, Helen ; Louw, Johanna ; Kidder, Dana. / Deceiving proteins! A case of lymphoma and high creatinine. In: BMJ Case Reports. 2017 ; Vol. 2017. pp. 1-3.
@article{07e2d5ee6f994c008d390db2752ee106,
title = "Deceiving proteins! A case of lymphoma and high creatinine",
abstract = "Estimation of kidney function by measuring serum creatinine is one the commonest laboratory tests conducted in clinical practice. Enzymatic methods are often used to measure serum creatinine. Clinicians should be aware of the limitations of these methods, such as test interference with paraproteins.We present a case of falsely elevated serum creatinine in a patient referred for renal biopsy. The combination of fluctuating creatinine and normal blood urea level was unusual. Serum protein electrophoresis revealed the presence of an IgM paraprotein. Further investigations confirmed an underlying diagnosis of lymphoplasmacytoid lymphoma. This case highlights how IgM paraprotein can interfere with creatinine estimation by enzymatic assay and the utility of alternative methods of estimating serum creatinine.",
author = "Metraiah, {El Hakem Abdelkarim} and Helen Regan and Johanna Louw and Dana Kidder",
year = "2017",
month = "1",
day = "23",
doi = "10.1136/bcr-2016-217946",
language = "English",
volume = "2017",
pages = "1--3",
journal = "BMJ Case Reports",
issn = "1757-790X",
publisher = "BMJ Publishing Group",

}

TY - JOUR

T1 - Deceiving proteins! A case of lymphoma and high creatinine

AU - Metraiah, El Hakem Abdelkarim

AU - Regan, Helen

AU - Louw, Johanna

AU - Kidder, Dana

PY - 2017/1/23

Y1 - 2017/1/23

N2 - Estimation of kidney function by measuring serum creatinine is one the commonest laboratory tests conducted in clinical practice. Enzymatic methods are often used to measure serum creatinine. Clinicians should be aware of the limitations of these methods, such as test interference with paraproteins.We present a case of falsely elevated serum creatinine in a patient referred for renal biopsy. The combination of fluctuating creatinine and normal blood urea level was unusual. Serum protein electrophoresis revealed the presence of an IgM paraprotein. Further investigations confirmed an underlying diagnosis of lymphoplasmacytoid lymphoma. This case highlights how IgM paraprotein can interfere with creatinine estimation by enzymatic assay and the utility of alternative methods of estimating serum creatinine.

AB - Estimation of kidney function by measuring serum creatinine is one the commonest laboratory tests conducted in clinical practice. Enzymatic methods are often used to measure serum creatinine. Clinicians should be aware of the limitations of these methods, such as test interference with paraproteins.We present a case of falsely elevated serum creatinine in a patient referred for renal biopsy. The combination of fluctuating creatinine and normal blood urea level was unusual. Serum protein electrophoresis revealed the presence of an IgM paraprotein. Further investigations confirmed an underlying diagnosis of lymphoplasmacytoid lymphoma. This case highlights how IgM paraprotein can interfere with creatinine estimation by enzymatic assay and the utility of alternative methods of estimating serum creatinine.

U2 - 10.1136/bcr-2016-217946

DO - 10.1136/bcr-2016-217946

M3 - Article

VL - 2017

SP - 1

EP - 3

JO - BMJ Case Reports

JF - BMJ Case Reports

SN - 1757-790X

ER -