@article{947713387a464eecb31a8b98173d02ab,
title = "Deciphering microbial landscapes of fish eggs to mitigate emerging diseases",
abstract = "Animals and plants are increasingly suffering from diseases caused by fungi and oomycetes. These emerging pathogens are now recognized as a global threat to biodiversity and food security. Among oomycetes, Saprolegnia species cause significant declines in fish and amphibian populations. Fish eggs have an immature adaptive immune system and depend on nonspecific innate defences to ward off pathogens. Here, meta-taxonomic analyses revealed that Atlantic salmon eggs are home to diverse fungal, oomycete and bacterial communities. Although virulent Saprolegnia isolates were found in all salmon egg samples, a low incidence of Saprolegniosis was strongly correlated with a high richness and abundance of specific commensal Actinobacteria, with the genus Frondihabitans (Microbacteriaceae) effectively inhibiting attachment of Saprolegniato salmon eggs. These results highlight that fundamental insights into microbial landscapes of fish eggs may provide new sustainable means to mitigate emerging diseases.The ISME Journal advance online publication, 27 March 2014; doi:10.1038/ismej.2014.44.",
keywords = "salmon, saprolegniosis, actinobacteria, microbiome, emerging pathogens",
author = "Yiying Liu and {de Bruijn}, Irene and Jack, {Allison Lh} and Keith Drynan and {van den Berg}, {Albert H} and Even Thoen and Vladimir Sandoval-Sierra and Ida Skaar and {van West}, Pieter and Javier Di{\'e}guez-Uribeondo and {van der Voort}, Menno and Rodrigo Mendes and Mark Mazzola and Raaijmakers, {Jos M}",
note = "We are grateful to Menno ter Veld and Geert Wiegertjes (Animal Sciences, Wageningen University, The Netherlands) for their advice, help and valuable suggestions for the in vivo experiments. We thank the Laboratory of Jean Beagle Ristraino (North Carolina State University, USA) for the provision of genomic DNA extraction protocol for oomycete isolates. We thank Viviane Cordovez da Cunha (Wageningen University) for her help in culturing and characterization of Actinobacteria. This work was financially supported by SAPRO (Sustainable Approaches to Reduce Oomycete (Saprolegnia) Infections in Aquaculture), a Marie Curie Initial Training Network funded by the European Commission (EC) under Framework Program 7. Javier Di{\'e}guez-Uribeondo was supported by grant of MINECO CGL2012-39357. PhyloChip hybridizations and initial data analyses were performed at Second Genome, CA, USA. This manuscript is publication number 5586 of Netherlands Institute of Ecology (NIOO-KNAW).",
year = "2014",
month = "10",
doi = "10.1038/ismej.2014.44",
language = "English",
volume = "8",
pages = "2002--2014",
journal = "The ISME Journal",
issn = "1751-7362",
publisher = "Nature Publishing Group",
number = "10",
}