Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum

Mostafa E Rateb, Hossam M Hassan, El-Shaimaa A Arafa, Marcel Jaspars, Rainer Ebel, Mostafa Ezzat Mohamed Rateb

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalNatural Product Communications
Volume9
Issue number4
Publication statusPublished - Apr 2014

Fingerprint

Rhododendron
Catechin
epicatechin
Glycosides
catechin
bromides
Flavonoids
spectral analysis
glycosides
fractionation
flavonoids
bioassays
cell lines
extracts
assays
Biological Assay
leaves
Cell Line
Neoplasms
neoplasm cells

Keywords

  • Antineoplastic Agents, Phytogenic
  • Cell Line, Tumor
  • Flavonoids
  • Glycosides
  • Humans
  • Molecular Structure
  • Plant Leaves
  • Rhododendron

Cite this

Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum. / Rateb, Mostafa E; Hassan, Hossam M; Arafa, El-Shaimaa A; Jaspars, Marcel; Ebel, Rainer; Rateb, Mostafa Ezzat Mohamed.

In: Natural Product Communications, Vol. 9, No. 4, 04.2014, p. 473-476.

Research output: Contribution to journalArticle

Rateb, Mostafa E ; Hassan, Hossam M ; Arafa, El-Shaimaa A ; Jaspars, Marcel ; Ebel, Rainer ; Rateb, Mostafa Ezzat Mohamed. / Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum. In: Natural Product Communications. 2014 ; Vol. 9, No. 4. pp. 473-476.
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AU - Hassan, Hossam M

AU - Arafa, El-Shaimaa A

AU - Jaspars, Marcel

AU - Ebel, Rainer

AU - Rateb, Mostafa Ezzat Mohamed

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AB - Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

KW - Antineoplastic Agents, Phytogenic

KW - Cell Line, Tumor

KW - Flavonoids

KW - Glycosides

KW - Humans

KW - Molecular Structure

KW - Plant Leaves

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