Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum

Mostafa E Rateb; Hossam M Hassan; El-Shaimaa A Arafa; Marcel Jaspars; Rainer Ebel; Mostafa Ezzat Mohamed Rateb

Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum

Mostafa E Rateb, Hossam M Hassan, El-Shaimaa A Arafa, Marcel Jaspars, Rainer Ebel, Mostafa Ezzat Mohamed Rateb

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

Original language	English
Pages (from-to)	473-476
Number of pages	4
Journal	Natural Product Communications
Volume	9
Issue number	4
Publication status	Published - Apr 2014

Keywords

Antineoplastic Agents, Phytogenic
Cell Line, Tumor
Flavonoids
Glycosides
Humans
Molecular Structure
Plant Leaves
Rhododendron

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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http://www.ncbi.nlm.nih.gov/pubmed/24868859

Cite this

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title = "Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum",

abstract = "Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.",

keywords = "Antineoplastic Agents, Phytogenic, Cell Line, Tumor, Flavonoids, Glycosides, Humans, Molecular Structure, Plant Leaves, Rhododendron",

author = "Rateb, {Mostafa E} and Hassan, {Hossam M} and Arafa, {El-Shaimaa A} and Marcel Jaspars and Rainer Ebel and Rateb, {Mostafa Ezzat Mohamed}",

year = "2014",

month = apr,

language = "English",

volume = "9",

pages = "473--476",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "Natural Product Communications",

number = "4",

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TY - JOUR

T1 - Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum

AU - Rateb, Mostafa E

AU - Hassan, Hossam M

AU - Arafa, El-Shaimaa A

AU - Jaspars, Marcel

AU - Ebel, Rainer

AU - Rateb, Mostafa Ezzat Mohamed

PY - 2014/4

Y1 - 2014/4

N2 - Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

AB - Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

KW - Antineoplastic Agents, Phytogenic

KW - Cell Line, Tumor

KW - Flavonoids

KW - Glycosides

KW - Humans

KW - Molecular Structure

KW - Plant Leaves

KW - Rhododendron

M3 - Article

C2 - 24868859

SN - 1934-578X

VL - 9

SP - 473

EP - 476

JO - Natural Product Communications

JF - Natural Product Communications

IS - 4

ER -

Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum

Abstract

Keywords

UN SDGs

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