Dectin-1

a role in antifungal defense and consequences of genetic polymorphisms in humans

Mohlopheni J Marakalala, Ann M Kerrigan, Gordon D Brown

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
Original languageEnglish
Pages (from-to)55-65
Number of pages11
JournalMammalian Genome
Volume22
Issue number1
Early online date11 Aug 2010
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Genetic Polymorphisms
Immunity
Pattern Recognition Receptors
Mycoses
Population
Genes
dectin 1

Keywords

  • animals
  • fungi
  • humans
  • membrane proteins
  • mycoses
  • nerve tissue proteins
  • polymorphism, genetic

Cite this

Dectin-1 : a role in antifungal defense and consequences of genetic polymorphisms in humans. / Marakalala, Mohlopheni J; Kerrigan, Ann M; Brown, Gordon D.

In: Mammalian Genome, Vol. 22, No. 1, 02.2011, p. 55-65.

Research output: Contribution to journalArticle

Marakalala, Mohlopheni J ; Kerrigan, Ann M ; Brown, Gordon D. / Dectin-1 : a role in antifungal defense and consequences of genetic polymorphisms in humans. In: Mammalian Genome. 2011 ; Vol. 22, No. 1. pp. 55-65.
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