Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

Mohlopheni J Marakalala, Ann M Kerrigan, Gordon D Brown

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
Original languageEnglish
Pages (from-to)55-65
Number of pages11
JournalMammalian Genome
Volume22
Issue number1
Early online date11 Aug 2010
DOIs
Publication statusPublished - Feb 2011

Keywords

  • animals
  • fungi
  • humans
  • membrane proteins
  • mycoses
  • nerve tissue proteins
  • polymorphism, genetic

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