The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
- membrane proteins
- nerve tissue proteins
- polymorphism, genetic
Marakalala, M. J., Kerrigan, A. M., & Brown, G. D. (2011). Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans. Mammalian Genome, 22(1), 55-65. https://doi.org/10.1007/s00335-010-9277-3