Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

Mohlopheni J Marakalala; Ann M Kerrigan; Gordon D Brown

doi:10.1007/s00335-010-9277-3

Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

Mohlopheni J Marakalala, Ann M Kerrigan, Gordon D Brown

Applied Medicine

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44 Citations (Scopus)

Abstract

The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.

Original language	English
Pages (from-to)	55-65
Number of pages	11
Journal	Mammalian Genome
Volume	22
Issue number	1
Early online date	11 Aug 2010
DOIs	https://doi.org/10.1007/s00335-010-9277-3
Publication status	Published - Feb 2011

Keywords

animals
fungi
humans
membrane proteins
mycoses
nerve tissue proteins
polymorphism, genetic

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10.1007/s00335-010-9277-3Licence: CC BY-NC

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KW - membrane proteins

KW - mycoses

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Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

Abstract

Keywords

UN SDGs

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