Dectin-1 and its role in antifungal immunity

Matti Kimberg, Gordon Douglas Brown

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The innate recognition of fungal pathogens is mediated by a variety of pattern recognition receptors (PRRs), although much interest has focussed on the Toll-like Receptors (TLR). More recently, however, there is growing appreciation that the non-TLRs have a major role in the control of infection with these organisms. One such molecule is Dectin-1, a C-type lectin-like receptor which induces numerous cellular responses upon recognition of fungal beta-glucans. Here we review our current understanding of the functions of Dectin-1 and the underlying molecular mechanisms, as well as explore the role of this receptor in antifungal immunity.
Original languageEnglish
Pages (from-to)631-636
Number of pages6
JournalMedical Mycology
Volume46
Issue number7
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Animals
  • Fungi
  • Humans
  • Immunity, Innate
  • Ligands
  • Membrane Proteins
  • Mycoses
  • Nerve Tissue Proteins
  • Signal Transduction
  • beta-Glucans
  • fungal diseases
  • Dectin-1
  • leukocyte receptor

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