Dectin-1 is not required for controlling Candida albicans colonisation of the gastrointestinal tract

Simon Vautier, Rebecca A Drummond, Pierre Redelinghuys, Graeme I Murray, Donna M Maccallum, Gordon D Brown

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Candida albicans is normally found as a commensal microbe, commonly colonising the gastrointestinal tract in humans. However, this fungus can also cause mucosal and systemic infections once immune function is compromised. Dectin-1 is an innate pattern recognition receptor essential for the control of fungal infections in both mice and humans, however its role in the control of C. albicans colonisation of the gastrointestinal tract has not been defined. Here, we demonstrate that in mice Dectin-1 is essential for the control of gastrointestinal invasion during systemic infection, with Dectin-1 deficiency associating with impaired fungal clearance and dysregulated cytokine production. Surprisingly, however, following oral infection Dectin-1 was not required for the control of mucosal colonisation of the gastrointestinal tract, either in terms of fungal burdens or cytokine response. Thus, in mice, Dectin-1 is essential for controlling systemic infection with C. albicans, but appears redundant for the control of gastrointestinal colonisation.
Original languageEnglish
Pages (from-to)4216-4222
Number of pages7
JournalInfection and Immunity
Volume80
Issue number12
Early online date17 Sep 2012
DOIs
Publication statusPublished - Dec 2012

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