Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo

Mohlopheni J Marakalala, David L Williams, Jennifer C Hoving, Rolf Engstad, Mihai G Netea, Gordon D Brown

Research output: Contribution to journalArticle

35 Citations (Scopus)
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Abstract

β-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these β-glucan rich compounds had marked effects in vivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.
Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalMicrobes and Infection
Volume15
Issue number6-7
Early online date19 Mar 2013
DOIs
Publication statusPublished - Jun 2013

Keywords

  • innate immunity
  • immunomodulation
  • dectin-1
  • beta-glucan
  • MODS
  • staphylococcus aureus

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