Abstract
β-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these β-glucan rich compounds had marked effects in vivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.
Original language | English |
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Pages (from-to) | 511-515 |
Number of pages | 5 |
Journal | Microbes and Infection |
Volume | 15 |
Issue number | 6-7 |
Early online date | 19 Mar 2013 |
DOIs | |
Publication status | Published - Jun 2013 |
Bibliographical note
Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.Keywords
- innate immunity
- immunomodulation
- dectin-1
- beta-glucan
- MODS
- staphylococcus aureus