Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo

Mohlopheni J Marakalala, David L Williams, Jennifer C Hoving, Rolf Engstad, Mihai G Netea, Gordon D Brown

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Abstract

β-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these β-glucan rich compounds had marked effects in vivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.
Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalMicrobes and Infection
Volume15
Issue number6-7
Early online date19 Mar 2013
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Glucans
Ligands
beta-Glucans
Zymosan
Immunomodulation
Multiple Organ Failure
Staphylococcus aureus
dectin 1
Infection

Keywords

  • innate immunity
  • immunomodulation
  • dectin-1
  • beta-glucan
  • MODS
  • staphylococcus aureus

Cite this

Marakalala, M. J., Williams, D. L., Hoving, J. C., Engstad, R., Netea, M. G., & Brown, G. D. (2013). Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo. Microbes and Infection, 15(6-7), 511-515. https://doi.org/10.1016/j.micinf.2013.03.002

Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo. / Marakalala, Mohlopheni J; Williams, David L; Hoving, Jennifer C; Engstad, Rolf; Netea, Mihai G; Brown, Gordon D.

In: Microbes and Infection, Vol. 15, No. 6-7, 06.2013, p. 511-515.

Research output: Contribution to journalArticle

Marakalala, MJ, Williams, DL, Hoving, JC, Engstad, R, Netea, MG & Brown, GD 2013, 'Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo', Microbes and Infection, vol. 15, no. 6-7, pp. 511-515. https://doi.org/10.1016/j.micinf.2013.03.002
Marakalala, Mohlopheni J ; Williams, David L ; Hoving, Jennifer C ; Engstad, Rolf ; Netea, Mihai G ; Brown, Gordon D. / Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo. In: Microbes and Infection. 2013 ; Vol. 15, No. 6-7. pp. 511-515.
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