Deleterious mutations can surf to high densities on the wave front of an expanding population

Justin M. J. Travis, Tamara Muenkemueller, Olivia J. Burton, Alex Best, Calvin Dytham, Karin Johst

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

There is an increasing recognition that evolutionary processes play a key role in determining the dynamics of range expansion. Recent work demonstrates that neutral mutations arising near the edge of a range expansion sometimes surf on the expanding front leading them rather than that leads to reach much greater spatial distribution and frequency than expected in stationary populations. Here, we extend this work and examine the surfing behavior of nonneutral mutations. Using an individual-based coupled-map lattice model, we confirm that, regardless of its fitness effects, the probability of survival of a new mutation depends strongly upon where it arises in relation to the expanding wave front. We demonstrate that the surfing effect can lead to deleterious mutations reaching high densities at an expanding front, even when they have substantial negative effects on fitness. Additionally, we highlight that this surfing phenomenon can occur for mutations that impact reproductive rate (i.e., number of offspring produced) as well as mutations that modify juvenile competitive ability. We suggest that these effects are likely to have important consequences for rates of spread and the evolution of spatially expanding populations.

Original languageEnglish
Pages (from-to)2334-2343
Number of pages10
JournalMolecular Biology and Evolution
Volume24
Issue number10
Early online date16 Aug 2007
DOIs
Publication statusPublished - Oct 2007

Keywords

  • evolution
  • invasion
  • range shifting
  • evolvability
  • epidemic
  • climate change
  • climate-change
  • fragmented landscapes
  • extinction risk
  • range expansion
  • forest trees
  • trade-off
  • dispersal
  • invasions
  • colonization

Cite this

Deleterious mutations can surf to high densities on the wave front of an expanding population. / Travis, Justin M. J.; Muenkemueller, Tamara; Burton, Olivia J.; Best, Alex; Dytham, Calvin; Johst, Karin.

In: Molecular Biology and Evolution, Vol. 24, No. 10, 10.2007, p. 2334-2343.

Research output: Contribution to journalArticle

Travis, Justin M. J. ; Muenkemueller, Tamara ; Burton, Olivia J. ; Best, Alex ; Dytham, Calvin ; Johst, Karin. / Deleterious mutations can surf to high densities on the wave front of an expanding population. In: Molecular Biology and Evolution. 2007 ; Vol. 24, No. 10. pp. 2334-2343.
@article{46c8a40013484fd4936593098032f660,
title = "Deleterious mutations can surf to high densities on the wave front of an expanding population",
abstract = "There is an increasing recognition that evolutionary processes play a key role in determining the dynamics of range expansion. Recent work demonstrates that neutral mutations arising near the edge of a range expansion sometimes surf on the expanding front leading them rather than that leads to reach much greater spatial distribution and frequency than expected in stationary populations. Here, we extend this work and examine the surfing behavior of nonneutral mutations. Using an individual-based coupled-map lattice model, we confirm that, regardless of its fitness effects, the probability of survival of a new mutation depends strongly upon where it arises in relation to the expanding wave front. We demonstrate that the surfing effect can lead to deleterious mutations reaching high densities at an expanding front, even when they have substantial negative effects on fitness. Additionally, we highlight that this surfing phenomenon can occur for mutations that impact reproductive rate (i.e., number of offspring produced) as well as mutations that modify juvenile competitive ability. We suggest that these effects are likely to have important consequences for rates of spread and the evolution of spatially expanding populations.",
keywords = "evolution, invasion, range shifting, evolvability, epidemic, climate change, climate-change, fragmented landscapes, extinction risk, range expansion, forest trees, trade-off, dispersal, invasions, colonization",
author = "Travis, {Justin M. J.} and Tamara Muenkemueller and Burton, {Olivia J.} and Alex Best and Calvin Dytham and Karin Johst",
year = "2007",
month = "10",
doi = "10.1093/molbev/msm167",
language = "English",
volume = "24",
pages = "2334--2343",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Deleterious mutations can surf to high densities on the wave front of an expanding population

AU - Travis, Justin M. J.

AU - Muenkemueller, Tamara

AU - Burton, Olivia J.

AU - Best, Alex

AU - Dytham, Calvin

AU - Johst, Karin

PY - 2007/10

Y1 - 2007/10

N2 - There is an increasing recognition that evolutionary processes play a key role in determining the dynamics of range expansion. Recent work demonstrates that neutral mutations arising near the edge of a range expansion sometimes surf on the expanding front leading them rather than that leads to reach much greater spatial distribution and frequency than expected in stationary populations. Here, we extend this work and examine the surfing behavior of nonneutral mutations. Using an individual-based coupled-map lattice model, we confirm that, regardless of its fitness effects, the probability of survival of a new mutation depends strongly upon where it arises in relation to the expanding wave front. We demonstrate that the surfing effect can lead to deleterious mutations reaching high densities at an expanding front, even when they have substantial negative effects on fitness. Additionally, we highlight that this surfing phenomenon can occur for mutations that impact reproductive rate (i.e., number of offspring produced) as well as mutations that modify juvenile competitive ability. We suggest that these effects are likely to have important consequences for rates of spread and the evolution of spatially expanding populations.

AB - There is an increasing recognition that evolutionary processes play a key role in determining the dynamics of range expansion. Recent work demonstrates that neutral mutations arising near the edge of a range expansion sometimes surf on the expanding front leading them rather than that leads to reach much greater spatial distribution and frequency than expected in stationary populations. Here, we extend this work and examine the surfing behavior of nonneutral mutations. Using an individual-based coupled-map lattice model, we confirm that, regardless of its fitness effects, the probability of survival of a new mutation depends strongly upon where it arises in relation to the expanding wave front. We demonstrate that the surfing effect can lead to deleterious mutations reaching high densities at an expanding front, even when they have substantial negative effects on fitness. Additionally, we highlight that this surfing phenomenon can occur for mutations that impact reproductive rate (i.e., number of offspring produced) as well as mutations that modify juvenile competitive ability. We suggest that these effects are likely to have important consequences for rates of spread and the evolution of spatially expanding populations.

KW - evolution

KW - invasion

KW - range shifting

KW - evolvability

KW - epidemic

KW - climate change

KW - climate-change

KW - fragmented landscapes

KW - extinction risk

KW - range expansion

KW - forest trees

KW - trade-off

KW - dispersal

KW - invasions

KW - colonization

U2 - 10.1093/molbev/msm167

DO - 10.1093/molbev/msm167

M3 - Article

VL - 24

SP - 2334

EP - 2343

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 10

ER -