Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic Cycles

Kevin J. Bown, Xavier Lambin, Nicholas H. Ogden, Michael Begon, Gill Telford, Zerai Woldehiwet, Richard J. Birtles

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The emerging tick-borne pathogen Anaplasma phagocytophilum is under increasing scrutiny for the existence of subpopulations that are adapted to different natural cycles. Here, we characterized the diversity of A. phagocytophilum genotypes circulating in a natural system that includes multiple hosts and at least 2 tick species, Ixodes ricinus and the small mammal specialist I. trianguliceps. We encountered numerous genotypes, but only 1 in rodents, with the remainder limited to deer and host-seeking I. ricinus ticks. The absence of the rodent-associated genotype from host-seeking I. ricinus ticks was notable because we demonstrated that rodents fed a large proportion of the I. ricinus larval population and that these larvae were abundant when infections caused by the rodent-associated genotype were prevalent. These observations are consistent with the conclusion that genotypically distinct subpopulations of A. phagocytophilum are restricted to coexisting but separate enzootic cycles and suggest that this restriction may result from specific vector compatibility.

Original languageEnglish
Pages (from-to)1948-1954
Number of pages7
JournalEmerging Infectious Diseases
Volume15
Issue number12
DOIs
Publication statusPublished - Dec 2009

Keywords

  • IXODES-RICINUS TICKS
  • HUMAN GRANULOCYTIC EHRLICHIOSIS
  • MICROTUS-AGRESTIS POPULATIONS
  • BORRELIA-BURGDORFERI
  • TRANSMISSION CYCLE
  • UNITED-KINGDOM
  • SMALL RODENTS
  • STRAINS
  • TRIANGULICEPS
  • DEER

Cite this

Bown, K. J., Lambin, X., Ogden, N. H., Begon, M., Telford, G., Woldehiwet, Z., & Birtles, R. J. (2009). Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic Cycles. Emerging Infectious Diseases, 15(12), 1948-1954. https://doi.org/10.3201/eid1512.090178