Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment

Stefania Spanò, Juan E Ugalde, Jorge E Galán

Research output: Contribution to journalArticlepeer-review

112 Citations (Scopus)

Abstract

Salmonella Typhi, an exclusive human pathogen and the cause of typhoid fever, expresses a functional cytolethal distending toxin for which only the active subunit, CdtB, has been identified. Here, we show that PltA and PltB, which are encoded in the same pathogenicity islet as cdtB, associate with CdtB to form a multipartite toxin. PltA and PltB are homologs of components of the pertussis toxin, including its ADP-ribosyl transferase subunit. We also show that PltA and PltB are required for the delivery of CdtB from an intracellular compartment to target cells via autocrine and paracrine pathways. We hypothesize that this toxin, which we have named "typhoid toxin," and its delivery mechanism may contribute to S. Typhi's unique virulence properties.
Original languageEnglish
Pages (from-to)30-38
Number of pages9
JournalCell Host & Microbe
Volume3
Issue number1
Early online date16 Jan 2008
DOIs
Publication statusPublished - 17 Jan 2008

Keywords

  • bacterial toxins
  • cell line
  • exotoxins
  • gene expression regulation, bacterial
  • humans
  • intestines
  • phagosomes
  • Salmonella typhi
  • vacuoles
  • virulence
  • MICROBIO
  • CELLBIO

Fingerprint Dive into the research topics of 'Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment'. Together they form a unique fingerprint.

Cite this