Demonstration of Melatonin-Binding Sites on the Pars Tuberalis of the Rat

Lynda Williams, Peter John Morgan

Research output: Contribution to journalComment/debate

132 Citations (Scopus)

Abstract

Melatonin-binding sites have previously been identified in the suprachiasmatic nucleus (SCN) and median eminence (ME) of the rat. We have further investigated the localization of melatonin-binding sites in the rat hypothalamus and pituitary using the ligand [125I] iodomelatonin and in-vitro autoradiography. The presence of specific melatonin-binding sites in the SCN is confirmed; however the second area of melatonin binding is identified as the pars tuberalis of the pituitary and not the ME as previously described. No other areas which bound melatonin were found in either the pituitary or the hypothalamus.

Original languageEnglish
Pages (from-to)R1-R3
Number of pages3
JournalJournal of Endocrinology
Volume119
Issue number1
DOIs
Publication statusPublished - Oct 1988

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