Denervation Increases Clenbuterol Sensitivity in Muscle from Young Rats

C A Maltin, Margaret Inkster Delday, Susan Hay, A G S Baillie

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Clenbuterol has been shown to ameliorate denervation-induced atrophy and, therefore, clearly has therapeutic potential in the treatment of muscle wasting conditions in man. Previous studies have used dosages in rats which would be unacceptable in clinical practice, but the present results show that denervated muscle has a greater sensitivity to the drug than innervated or cardiac muscle. Fiber hypertrophy and an increase in protein and RNA content could be observed in denervated muscles but not in innervated muscles at a dose of 10-mu-g/kg body weight. When considered on a metabolic body weight basis, the effective dose in rats and the "safe" dose in man are surprisingly comparable. The observations imply that there is good reason to suppose that clenbuterol could be effective in ameliorating similar wasting conditions in man.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalMuscle & nerve
Volume15
Issue number2
Publication statusPublished - Feb 1992

Keywords

  • MUSCLE
  • DENERVATION
  • CLENBUTEROL
  • BETA-AGONIST
  • ATROPHY
  • GROWTH
  • BETA-ADRENERGIC RECEPTORS
  • SKELETAL-MUSCLE
  • AGONIST CLENBUTEROL
  • BODY-COMPOSITION
  • DEPOSITION
  • FAT
  • INHIBITION
  • METABOLISM
  • INVITRO
  • muscle
  • denervation
  • clenbuterol
  • beta-agonist
  • atrophy
  • growth

Cite this

Maltin, C. A., Delday, M. I., Hay, S., & Baillie, A. G. S. (1992). Denervation Increases Clenbuterol Sensitivity in Muscle from Young Rats. Muscle & nerve, 15(2), 188-192.

Denervation Increases Clenbuterol Sensitivity in Muscle from Young Rats. / Maltin, C A ; Delday, Margaret Inkster; Hay, Susan; Baillie, A G S .

In: Muscle & nerve, Vol. 15, No. 2, 02.1992, p. 188-192.

Research output: Contribution to journalArticle

Maltin, CA, Delday, MI, Hay, S & Baillie, AGS 1992, 'Denervation Increases Clenbuterol Sensitivity in Muscle from Young Rats', Muscle & nerve, vol. 15, no. 2, pp. 188-192.
Maltin, C A ; Delday, Margaret Inkster ; Hay, Susan ; Baillie, A G S . / Denervation Increases Clenbuterol Sensitivity in Muscle from Young Rats. In: Muscle & nerve. 1992 ; Vol. 15, No. 2. pp. 188-192.
@article{b601ef14af99428aa55322fedf7b83fc,
title = "Denervation Increases Clenbuterol Sensitivity in Muscle from Young Rats",
abstract = "Clenbuterol has been shown to ameliorate denervation-induced atrophy and, therefore, clearly has therapeutic potential in the treatment of muscle wasting conditions in man. Previous studies have used dosages in rats which would be unacceptable in clinical practice, but the present results show that denervated muscle has a greater sensitivity to the drug than innervated or cardiac muscle. Fiber hypertrophy and an increase in protein and RNA content could be observed in denervated muscles but not in innervated muscles at a dose of 10-mu-g/kg body weight. When considered on a metabolic body weight basis, the effective dose in rats and the {"}safe{"} dose in man are surprisingly comparable. The observations imply that there is good reason to suppose that clenbuterol could be effective in ameliorating similar wasting conditions in man.",
keywords = "MUSCLE, DENERVATION, CLENBUTEROL, BETA-AGONIST, ATROPHY, GROWTH, BETA-ADRENERGIC RECEPTORS, SKELETAL-MUSCLE, AGONIST CLENBUTEROL, BODY-COMPOSITION, DEPOSITION, FAT, INHIBITION, METABOLISM, INVITRO, muscle, denervation, clenbuterol, beta-agonist, atrophy, growth",
author = "Maltin, {C A} and Delday, {Margaret Inkster} and Susan Hay and Baillie, {A G S}",
year = "1992",
month = "2",
language = "English",
volume = "15",
pages = "188--192",
journal = "Muscle & nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Denervation Increases Clenbuterol Sensitivity in Muscle from Young Rats

AU - Maltin, C A

AU - Delday, Margaret Inkster

AU - Hay, Susan

AU - Baillie, A G S

PY - 1992/2

Y1 - 1992/2

N2 - Clenbuterol has been shown to ameliorate denervation-induced atrophy and, therefore, clearly has therapeutic potential in the treatment of muscle wasting conditions in man. Previous studies have used dosages in rats which would be unacceptable in clinical practice, but the present results show that denervated muscle has a greater sensitivity to the drug than innervated or cardiac muscle. Fiber hypertrophy and an increase in protein and RNA content could be observed in denervated muscles but not in innervated muscles at a dose of 10-mu-g/kg body weight. When considered on a metabolic body weight basis, the effective dose in rats and the "safe" dose in man are surprisingly comparable. The observations imply that there is good reason to suppose that clenbuterol could be effective in ameliorating similar wasting conditions in man.

AB - Clenbuterol has been shown to ameliorate denervation-induced atrophy and, therefore, clearly has therapeutic potential in the treatment of muscle wasting conditions in man. Previous studies have used dosages in rats which would be unacceptable in clinical practice, but the present results show that denervated muscle has a greater sensitivity to the drug than innervated or cardiac muscle. Fiber hypertrophy and an increase in protein and RNA content could be observed in denervated muscles but not in innervated muscles at a dose of 10-mu-g/kg body weight. When considered on a metabolic body weight basis, the effective dose in rats and the "safe" dose in man are surprisingly comparable. The observations imply that there is good reason to suppose that clenbuterol could be effective in ameliorating similar wasting conditions in man.

KW - MUSCLE

KW - DENERVATION

KW - CLENBUTEROL

KW - BETA-AGONIST

KW - ATROPHY

KW - GROWTH

KW - BETA-ADRENERGIC RECEPTORS

KW - SKELETAL-MUSCLE

KW - AGONIST CLENBUTEROL

KW - BODY-COMPOSITION

KW - DEPOSITION

KW - FAT

KW - INHIBITION

KW - METABOLISM

KW - INVITRO

KW - muscle

KW - denervation

KW - clenbuterol

KW - beta-agonist

KW - atrophy

KW - growth

M3 - Article

VL - 15

SP - 188

EP - 192

JO - Muscle & nerve

JF - Muscle & nerve

SN - 0148-639X

IS - 2

ER -