Dense active matter model of motion patterns in confluent cell monolayers

Silke Henkes (Corresponding Author), Kaja Kostanjevec, J. Martin Collinson, Rastko Sknepnek (Corresponding Author), Eric Bertin (Corresponding Author)

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Abstract

Epithelial cell monolayers show remarkable displacement and velocity correlations over distances of ten or more cell sizes that are reminiscent of supercooled liquids and active nematics. We show that many observed features can be described within the framework of dense active matter, and argue that persistent uncoordinated cell motility coupled to the collective elastic modes of the cell sheet is sufficient to produce swirl-like correlations. We obtain this result using both continuum active linear elasticity and a normal modes formalism, and validate analytical predictions with numerical simulations of two agent-based cell models, soft elastic particles and the self-propelled Voronoi model together with in-vitro experiments of confluent corneal epithelial cell sheets. Simulations and normal mode analysis perfectly match when tissue-level reorganisation occurs on times longer than the persistence time of cell motility. Our analytical model quantitatively matches measured velocity correlation functions over more than a decade with a single fitting parameter.

Original languageEnglish
Article number1405
JournalNature Communications
Volume11
DOIs
Publication statusPublished - 16 Mar 2020

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Keywords

  • biological physics
  • biophysics
  • computational biophysics
  • motility
  • statistical physics, thermodynamics and nonlinear dynamics

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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