Dependence on Dectin-1 Varies With Multiple Candida Species

Aiysha Thompson, James S Griffiths, Louise Walker, Diogo M da Fonseca, Keunsook K Lee, Philip R Taylor, Neil A R Gow, Selinda J Orr (Corresponding Author)

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17 Citations (Scopus)
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Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to C. albicans and C. glabrata, however, whether Dectin-1 is important for host defense against C. tropicalis or C. parapsilosis is unknown. Therefore, we compared the involvement of Dectin-1 in response to these four diverse Candida spp. We found that Dectin-1 mediates innate cytokine responses to these Candida spp. in a species- and cell-dependent manner. Dectin-1 KO mice succumbed to infection with highly virulent C. albicans while they mostly survived infection with less virulent Candida spp. However, Dectin-1 KO mice displayed increased fungal burden following infection with each Candida spp. Additionally, T cells from Dectin-1 KO mice displayed enhanced effector functions likely due to the inability of Dectin-1 KO mice to clear the infections. Together, these data indicate that Dectin-1 is important for host defense to multiple Candida spp., although the specific roles for Dectin-1 varies with different Candida spp.

Original languageEnglish
Article number1800
Number of pages12
JournalFrontiers in Microbiology
Publication statusPublished - 6 Aug 2019


  • Dectin-1
  • candida spp.
  • macrophages
  • dendritic cells
  • T cells
  • Candida spp
  • Dendritic cells
  • Macrophages


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