Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema

Anna Berekméri; Anne Latzko; Adewonuola Alase; Tom Macleod; Joseph S Ainscough; Philip Laws; Mark Goodfield; Andrew Wright; Philip Helliwell; Sara Edward; Gordon D Brown; Delyth M Reid; Joerg Wenzel; Martin Stacey; Miriam Wittmann

doi:10.1016/j.jaci.2018.04.031

Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema

Anna Berekméri, Anne Latzko, Adewonuola Alase, Tom Macleod, Joseph S Ainscough, Philip Laws, Mark Goodfield, Andrew Wright, Philip Helliwell, Sara Edward, Gordon D Brown, Delyth M Reid, Joerg Wenzel, Martin Stacey, Miriam Wittmann (Corresponding Author)

Applied Medicine

Research output: Contribution to journal › Letter › peer-review

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Abstract

This report demonstrates that sampling and detection of IL-36γ protein by non-invasive tape stripping of skin lesion provides a highly sensitive and selective diagnostic for psoriatic inflammation.

Original language	English
Pages (from-to)	988-991
Number of pages	4
Journal	Journal of Allergy and Clinical Immunology
Volume	142
Issue number	3
Early online date	18 May 2018
DOIs	https://doi.org/10.1016/j.jaci.2018.04.031
Publication status	Published - Sept 2018

Bibliographical note

This project was mainly supported by a 2014 Pfizer Inflammation Competitive Research Programme (ICRP). In addition, assay development support was received by MRC grant MR/M01942X/1. GDB and DMR were funded by the Wellcome Trust (102705, 97377), the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1).

Some of the samples included in the atopic dermatitis comparator group were acquired in the context of the National Institute for Health Research (NIHR) funded ALPHA trial (EUDRACT 2014-004741-27) – explorative biomarker substudy. The ALPHA trial was developed in collaboration with the Clinical Trials Research Unit at the University of Leeds with support from the UK Dermatology Clinical Trials Network (UK DCTN). The UK DCTN is grateful to the British Association of Dermatologists and the University of Nottingham for financial support of the Network.

This research is also supported by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

Keywords

Psoriasis
Atopic Dermatitis
Eczema
IL-36
Diagnostic
biomarker

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Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema (2)
This is an open access articleunder the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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Berekméri, A., Latzko, A., Alase, A., Macleod, T., Ainscough, J. S., Laws, P., Goodfield, M., Wright, A., Helliwell, P., Edward, S., Brown, G. D., Reid, D. M., Wenzel, J., Stacey, M., & Wittmann, M. (2018). Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema. Journal of Allergy and Clinical Immunology, 142(3), 988-991. https://doi.org/10.1016/j.jaci.2018.04.031

Berekméri, A, Latzko, A, Alase, A, Macleod, T, Ainscough, JS, Laws, P, Goodfield, M, Wright, A, Helliwell, P, Edward, S, Brown, GD, Reid, DM, Wenzel, J, Stacey, M & Wittmann, M 2018, 'Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema', Journal of Allergy and Clinical Immunology, vol. 142, no. 3, pp. 988-991. https://doi.org/10.1016/j.jaci.2018.04.031

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title = "Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema",

abstract = "This report demonstrates that sampling and detection of IL-36γ protein by non-invasive tape stripping of skin lesion provides a highly sensitive and selective diagnostic for psoriatic inflammation.",

keywords = "Psoriasis, Atopic Dermatitis, Eczema, IL-36, Diagnostic, biomarker",

author = "Anna Berekm{\'e}ri and Anne Latzko and Adewonuola Alase and Tom Macleod and Ainscough, {Joseph S} and Philip Laws and Mark Goodfield and Andrew Wright and Philip Helliwell and Sara Edward and Brown, {Gordon D} and Reid, {Delyth M} and Joerg Wenzel and Martin Stacey and Miriam Wittmann",

note = "This project was mainly supported by a 2014 Pfizer Inflammation Competitive Research Programme (ICRP). In addition, assay development support was received by MRC grant MR/M01942X/1. GDB and DMR were funded by the Wellcome Trust (102705, 97377), the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). Some of the samples included in the atopic dermatitis comparator group were acquired in the context of the National Institute for Health Research (NIHR) funded ALPHA trial (EUDRACT 2014-004741-27) – explorative biomarker substudy. The ALPHA trial was developed in collaboration with the Clinical Trials Research Unit at the University of Leeds with support from the UK Dermatology Clinical Trials Network (UK DCTN). The UK DCTN is grateful to the British Association of Dermatologists and the University of Nottingham for financial support of the Network. This research is also supported by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.",

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doi = "10.1016/j.jaci.2018.04.031",

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AU - Berekméri, Anna

AU - Latzko, Anne

AU - Alase, Adewonuola

AU - Macleod, Tom

AU - Ainscough, Joseph S

AU - Laws, Philip

AU - Goodfield, Mark

AU - Wright, Andrew

AU - Helliwell, Philip

AU - Edward, Sara

AU - Brown, Gordon D

AU - Reid, Delyth M

AU - Wenzel, Joerg

AU - Stacey, Martin

AU - Wittmann, Miriam

N1 - This project was mainly supported by a 2014 Pfizer Inflammation Competitive Research Programme (ICRP). In addition, assay development support was received by MRC grant MR/M01942X/1. GDB and DMR were funded by the Wellcome Trust (102705, 97377), the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). Some of the samples included in the atopic dermatitis comparator group were acquired in the context of the National Institute for Health Research (NIHR) funded ALPHA trial (EUDRACT 2014-004741-27) – explorative biomarker substudy. The ALPHA trial was developed in collaboration with the Clinical Trials Research Unit at the University of Leeds with support from the UK Dermatology Clinical Trials Network (UK DCTN). The UK DCTN is grateful to the British Association of Dermatologists and the University of Nottingham for financial support of the Network. This research is also supported by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

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N2 - This report demonstrates that sampling and detection of IL-36γ protein by non-invasive tape stripping of skin lesion provides a highly sensitive and selective diagnostic for psoriatic inflammation.

AB - This report demonstrates that sampling and detection of IL-36γ protein by non-invasive tape stripping of skin lesion provides a highly sensitive and selective diagnostic for psoriatic inflammation.

KW - Psoriasis

KW - Atopic Dermatitis

KW - Eczema

KW - IL-36

KW - Diagnostic

KW - biomarker

U2 - 10.1016/j.jaci.2018.04.031

DO - 10.1016/j.jaci.2018.04.031

M3 - Letter

C2 - 29782895

SN - 0091-6749

VL - 142

SP - 988

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JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 3

ER -

Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema

Abstract

Bibliographical note

Keywords

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