Detection of time-, frequency- and direction-resolved communication within brain networks

Barry Crouch, Linda Sommerlade, Peter Veselcic, Gernot Riedel, Bjoern Schelter, Bettina Platt

Research output: Contribution to journalArticle

2 Citations (Scopus)
8 Downloads (Pure)

Abstract

Electroencephalography (EEG) records fast-changing neuronal signalling and communication and thus can offer a deep understanding of cognitive processes. However, traditional data analyses which employ the Fast-Fourier Transform (FFT) have been of limited use as they do not allow time- and frequency-resolved tracking of brain activity and detection of directional connectivity. Here, we applied advanced qEEG tools using autoregressive (AR) modelling, alongside traditional approaches, to murine data sets from common research scenarios: (a) the effect of age on resting EEG; (b) drug actions on non-rapid eye movement (NREM) sleep EEG (pharmaco-EEG); and (c) dynamic EEG profiles during correct vs incorrect spontaneous alternation responses in the Y-maze. AR analyses of short data strips reliably detected age- and drug-induced spectral EEG changes, while renormalized partial directed coherence (rPDC) reported direction- and time-resolved connectivity dynamics in mice. Our approach allows for the first time inference of behaviour- and stage-dependent data in a time- and frequency-resolved manner, and offers insights into brain networks that underlie working memory processing beyond what can be achieved with traditional methods.
Original languageEnglish
Article number1825
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 29 Jan 2018

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Electroencephalography
Communication
Brain
Fourier Analysis
Eye Movements
Short-Term Memory
Pharmaceutical Preparations
Direction compound
Sleep
Research

Keywords

  • applied mathematics
  • neurophysiology
  • neuroscience

Cite this

Detection of time-, frequency- and direction-resolved communication within brain networks. / Crouch, Barry; Sommerlade, Linda; Veselcic, Peter; Riedel, Gernot; Schelter, Bjoern; Platt, Bettina.

In: Scientific Reports, Vol. 8, 1825, 29.01.2018.

Research output: Contribution to journalArticle

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abstract = "Electroencephalography (EEG) records fast-changing neuronal signalling and communication and thus can offer a deep understanding of cognitive processes. However, traditional data analyses which employ the Fast-Fourier Transform (FFT) have been of limited use as they do not allow time- and frequency-resolved tracking of brain activity and detection of directional connectivity. Here, we applied advanced qEEG tools using autoregressive (AR) modelling, alongside traditional approaches, to murine data sets from common research scenarios: (a) the effect of age on resting EEG; (b) drug actions on non-rapid eye movement (NREM) sleep EEG (pharmaco-EEG); and (c) dynamic EEG profiles during correct vs incorrect spontaneous alternation responses in the Y-maze. AR analyses of short data strips reliably detected age- and drug-induced spectral EEG changes, while renormalized partial directed coherence (rPDC) reported direction- and time-resolved connectivity dynamics in mice. Our approach allows for the first time inference of behaviour- and stage-dependent data in a time- and frequency-resolved manner, and offers insights into brain networks that underlie working memory processing beyond what can be achieved with traditional methods.",
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AU - Veselcic, Peter

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AU - Schelter, Bjoern

AU - Platt, Bettina

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