Determinants and impact of suboptimal asthma control in Europe: The INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study

Fulvio Braido, Guy Brusselle, Daniele Guastalla, Eleonora Ingrassia, Gabriele Nicolini, David Price, Nicolas Roche, Joan B. Soriano, Heinrich Worth, LIAISON Study Group

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)
10 Downloads (Pure)


BACKGROUND: According to the Global Initiative of Asthma, the aim of asthma treatment is to gain and maintain control. In the INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study, we evaluated the level of asthma control and quality of life (QoL), as well as their determinants and impact in a population consulting specialist settings.

METHODS: LIAISON is a prospective, multicentre, observational study with a cross-sectional and a 12-month longitudinal phase. Adults with an asthma diagnosis since at least 6 months, receiving the same asthma treatment in the 4 weeks before enrolment were included. Asthma control was assessed with the 6-item Asthma Control Questionnaire (ACQ) and QoL with the MiniAsthma Quality of Life Questionnaire (MiniAQLQ).

RESULTS: Overall, 8111 asthmatic patients were enrolled in 12 European countries. Asthma control was suboptimal in 56.5 % of patients and it was associated with poorer asthma-related QoL, higher risk of exacerbations and greater consumption of healthcare resources. Variables associated with suboptimal control were age, gender, obesity, smoking and comorbidities. Major determinants of poor asthma control were seasonal worsening and persisting exposure to allergens/irritants/triggers, followed by treatment-related issues.

CONCLUSIONS: The cross-sectional phase results confirm that suboptimal control is frequent and has a high individual and economic impact.

TRIAL REGISTRATION: The identifier is NCT01567280 .

Original languageEnglish
Article number51
Pages (from-to)1-10
Number of pages10
JournalRespiratory Research
Issue number1
Publication statusPublished - 14 May 2016


Dive into the research topics of 'Determinants and impact of suboptimal asthma control in Europe: The INTERNATIONA<i>L</i> CROSS-SECT<i>I</i>ON<i>A</i>L AND LONG<i>I</i>TUDINAL ASSESSMENT ON A<i>S</i>THMA CO<i>N</i>TROL (LIAISON) study'. Together they form a unique fingerprint.

Cite this