Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

Rahim Kanji, Ying X Gue, Mohamed F Farag, Neil H Spencer, Nicola J Mutch, Diana A Gorog* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis.

Original languageEnglish
Pages (from-to)1069-1082
Number of pages14
JournalJACC: Basic to Translational Science
Volume7
Issue number11
Early online date14 Nov 2022
DOIs
Publication statusPublished - Nov 2022

Keywords

  • fibrinolysis
  • Myocardial infarction
  • platelet function
  • thrombosis

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