Developing a core outcome set in interventions to prevent stillbirth: A systematic review on variations of outcome reporting

Bobae Veronica Kim; Edoardo C Aromataris; Willem de Lint; Philippa Middleton; Rosemary Townsent; Asma Khalil; James M Duffy; Vicki Flenady; Shakila Thangaratinam; Ben W Mol

doi:10.1016/j.ejogrb.2020.12.036

Developing a core outcome set in interventions to prevent stillbirth: A systematic review on variations of outcome reporting

Bobae Veronica Kim, Edoardo C Aromataris, Willem de Lint, Philippa Middleton, Rosemary Townsent, Asma Khalil, James M Duffy, Vicki Flenady, Shakila Thangaratinam, Ben W Mol^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

OBJECTIVE: To determine which outcomes have been previously reported in previous stillbirth prevention studies.

RESEARCH DESIGN: Systematic review of reviews: We searched the Cochrane Database of Systematic Reviews, EMBASE and Pubmed for systematic reviews and meta- analyses investigating interventions to prevent stillbirth and its major risk factors.

DATA COLLECTION AND ANALYSIS: Two reviewers identified and extracted outcomes independently. Outcomes were categorised under relevant domains for analysis. Frequency of each outcome was also determined.

MAIN RESULTS: From 51 eligible reviews, 16 reviews addressed stillbirth prevention specifically while 35 reviews evaluated the efficacies of prevention or management of the eight major risk factors of stillbirth. Two hundred and thirty-seven outcomes were extracted, including 150 maternal outcomes and 87 offspring outcomes. Stillbirth (35/51), perinatal mortality (34/51) and neonatal mortality (33/51) were the most commonly reported outcomes followed by birthweight (29/51), caesarean section (28/51) and preeclampsia/eclampsia (23/51). Self-reported mother/family focused outcomes on their experiences and views were reported in 10/51 reviews.

CONCLUSION: In studies evaluating prevention of stillbirth there is a large variety in outcomes, with discrepancies in nomenclature and measurements. Woman/family-centred outcomes are often missing from studies. There is a need for a core outcome sets agreed by all stakeholders containing the recommended minimum data to be reported in future studies investigating prevention of stillbirth.

Original language	English
Pages (from-to)	196-206
Number of pages	11
Journal	European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume	259
Early online date	31 Dec 2020
DOIs	https://doi.org/10.1016/j.ejogrb.2020.12.036
Publication status	Published - Apr 2021

Bibliographical note

Funding
The COSTIL project was funded by Stillbirth Foundation Australia, The University of Adelaide and The Stillbirth Centre for Research Excellence (CRE), The University of Queensland. The project protocol, collection of data and analyses were designed and carried out independently from the funders.

Keywords

Cesarean Section
Female
Humans
Infant, Newborn
Outcome Assessment, Health Care
Perinatal Mortality
Pregnancy
Stillbirth/epidemiology
Systematic Reviews as Topic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ejogrb.2020.12.036Licence: Unspecified

Cite this

Kim, B. V., Aromataris, E. C., de Lint, W., Middleton, P., Townsent, R., Khalil, A., Duffy, J. M., Flenady, V., Thangaratinam, S., & Mol, B. W. (2021). Developing a core outcome set in interventions to prevent stillbirth: A systematic review on variations of outcome reporting. European Journal of Obstetrics & Gynecology and Reproductive Biology, 259, 196-206. https://doi.org/10.1016/j.ejogrb.2020.12.036

Developing a core outcome set in interventions to prevent stillbirth: A systematic review on variations of outcome reporting. / Kim, Bobae Veronica; Aromataris, Edoardo C; de Lint, Willem et al.
In: European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 259, 04.2021, p. 196-206.

Research output: Contribution to journal › Review article › peer-review

Kim, BV, Aromataris, EC, de Lint, W, Middleton, P, Townsent, R, Khalil, A, Duffy, JM, Flenady, V, Thangaratinam, S & Mol, BW 2021, 'Developing a core outcome set in interventions to prevent stillbirth: A systematic review on variations of outcome reporting', European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 259, pp. 196-206. https://doi.org/10.1016/j.ejogrb.2020.12.036

@article{1cd07da5b8f548f2bed420ab0ae52745,

title = "Developing a core outcome set in interventions to prevent stillbirth: A systematic review on variations of outcome reporting",

abstract = "OBJECTIVE: To determine which outcomes have been previously reported in previous stillbirth prevention studies.RESEARCH DESIGN: Systematic review of reviews: We searched the Cochrane Database of Systematic Reviews, EMBASE and Pubmed for systematic reviews and meta- analyses investigating interventions to prevent stillbirth and its major risk factors.DATA COLLECTION AND ANALYSIS: Two reviewers identified and extracted outcomes independently. Outcomes were categorised under relevant domains for analysis. Frequency of each outcome was also determined.MAIN RESULTS: From 51 eligible reviews, 16 reviews addressed stillbirth prevention specifically while 35 reviews evaluated the efficacies of prevention or management of the eight major risk factors of stillbirth. Two hundred and thirty-seven outcomes were extracted, including 150 maternal outcomes and 87 offspring outcomes. Stillbirth (35/51), perinatal mortality (34/51) and neonatal mortality (33/51) were the most commonly reported outcomes followed by birthweight (29/51), caesarean section (28/51) and preeclampsia/eclampsia (23/51). Self-reported mother/family focused outcomes on their experiences and views were reported in 10/51 reviews.CONCLUSION: In studies evaluating prevention of stillbirth there is a large variety in outcomes, with discrepancies in nomenclature and measurements. Woman/family-centred outcomes are often missing from studies. There is a need for a core outcome sets agreed by all stakeholders containing the recommended minimum data to be reported in future studies investigating prevention of stillbirth.",

keywords = "Cesarean Section, Female, Humans, Infant, Newborn, Outcome Assessment, Health Care, Perinatal Mortality, Pregnancy, Stillbirth/epidemiology, Systematic Reviews as Topic",

author = "Kim, {Bobae Veronica} and Aromataris, {Edoardo C} and {de Lint}, Willem and Philippa Middleton and Rosemary Townsent and Asma Khalil and Duffy, {James M} and Vicki Flenady and Shakila Thangaratinam and Mol, {Ben W}",

note = "Funding The COSTIL project was funded by Stillbirth Foundation Australia, The University of Adelaide and The Stillbirth Centre for Research Excellence (CRE), The University of Queensland. The project protocol, collection of data and analyses were designed and carried out independently from the funders.",

year = "2021",

month = apr,

doi = "10.1016/j.ejogrb.2020.12.036",

language = "English",

volume = "259",

pages = "196--206",

journal = "European Journal of Obstetrics & Gynecology and Reproductive Biology",

issn = "0301-2115",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Developing a core outcome set in interventions to prevent stillbirth

T2 - A systematic review on variations of outcome reporting

AU - Kim, Bobae Veronica

AU - Aromataris, Edoardo C

AU - de Lint, Willem

AU - Middleton, Philippa

AU - Townsent, Rosemary

AU - Khalil, Asma

AU - Duffy, James M

AU - Flenady, Vicki

AU - Thangaratinam, Shakila

AU - Mol, Ben W

N1 - Funding The COSTIL project was funded by Stillbirth Foundation Australia, The University of Adelaide and The Stillbirth Centre for Research Excellence (CRE), The University of Queensland. The project protocol, collection of data and analyses were designed and carried out independently from the funders.

PY - 2021/4

Y1 - 2021/4

N2 - OBJECTIVE: To determine which outcomes have been previously reported in previous stillbirth prevention studies.RESEARCH DESIGN: Systematic review of reviews: We searched the Cochrane Database of Systematic Reviews, EMBASE and Pubmed for systematic reviews and meta- analyses investigating interventions to prevent stillbirth and its major risk factors.DATA COLLECTION AND ANALYSIS: Two reviewers identified and extracted outcomes independently. Outcomes were categorised under relevant domains for analysis. Frequency of each outcome was also determined.MAIN RESULTS: From 51 eligible reviews, 16 reviews addressed stillbirth prevention specifically while 35 reviews evaluated the efficacies of prevention or management of the eight major risk factors of stillbirth. Two hundred and thirty-seven outcomes were extracted, including 150 maternal outcomes and 87 offspring outcomes. Stillbirth (35/51), perinatal mortality (34/51) and neonatal mortality (33/51) were the most commonly reported outcomes followed by birthweight (29/51), caesarean section (28/51) and preeclampsia/eclampsia (23/51). Self-reported mother/family focused outcomes on their experiences and views were reported in 10/51 reviews.CONCLUSION: In studies evaluating prevention of stillbirth there is a large variety in outcomes, with discrepancies in nomenclature and measurements. Woman/family-centred outcomes are often missing from studies. There is a need for a core outcome sets agreed by all stakeholders containing the recommended minimum data to be reported in future studies investigating prevention of stillbirth.

AB - OBJECTIVE: To determine which outcomes have been previously reported in previous stillbirth prevention studies.RESEARCH DESIGN: Systematic review of reviews: We searched the Cochrane Database of Systematic Reviews, EMBASE and Pubmed for systematic reviews and meta- analyses investigating interventions to prevent stillbirth and its major risk factors.DATA COLLECTION AND ANALYSIS: Two reviewers identified and extracted outcomes independently. Outcomes were categorised under relevant domains for analysis. Frequency of each outcome was also determined.MAIN RESULTS: From 51 eligible reviews, 16 reviews addressed stillbirth prevention specifically while 35 reviews evaluated the efficacies of prevention or management of the eight major risk factors of stillbirth. Two hundred and thirty-seven outcomes were extracted, including 150 maternal outcomes and 87 offspring outcomes. Stillbirth (35/51), perinatal mortality (34/51) and neonatal mortality (33/51) were the most commonly reported outcomes followed by birthweight (29/51), caesarean section (28/51) and preeclampsia/eclampsia (23/51). Self-reported mother/family focused outcomes on their experiences and views were reported in 10/51 reviews.CONCLUSION: In studies evaluating prevention of stillbirth there is a large variety in outcomes, with discrepancies in nomenclature and measurements. Woman/family-centred outcomes are often missing from studies. There is a need for a core outcome sets agreed by all stakeholders containing the recommended minimum data to be reported in future studies investigating prevention of stillbirth.

KW - Cesarean Section

KW - Female

KW - Humans

KW - Infant, Newborn

KW - Outcome Assessment, Health Care

KW - Perinatal Mortality

KW - Pregnancy

KW - Stillbirth/epidemiology

KW - Systematic Reviews as Topic

U2 - 10.1016/j.ejogrb.2020.12.036

DO - 10.1016/j.ejogrb.2020.12.036

M3 - Review article

C2 - 33583657

SN - 0301-2115

VL - 259

SP - 196

EP - 206

JO - European Journal of Obstetrics & Gynecology and Reproductive Biology

JF - European Journal of Obstetrics & Gynecology and Reproductive Biology

ER -

Developing a core outcome set in interventions to prevent stillbirth: A systematic review on variations of outcome reporting

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this