Development of neural stem cell in the adult brain

Xin Duan, Eunchai Kang, Cindy Y Liu, Guo-Li Ming, Hongjun Song

Research output: Contribution to journalReview article

236 Citations (Scopus)

Abstract

New neurons are continuously generated in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles throughout life. The origin of these new neurons is believed to be from multipotent adult neural stem cells. Aided by new methodologies, significant progress has been made in the characterization of neural stem cells and their development in the adult brain. Recent studies have also begun to reveal essential extrinsic and intrinsic molecular mechanisms that govern sequential steps of adult neurogenesis in the hippocampus and subventricular zone/olfactory bulb, from proliferation and fate specification of neural progenitors to maturation, navigation, and synaptic integration of the neuronal progeny. Future identification of molecular mechanisms and physiological functions of adult neurogenesis will provide further insight into the plasticity and regenerative capacity of the mature central nervous system.

Original languageEnglish
Pages (from-to)108-15
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume18
Issue number1
DOIs
Publication statusPublished - 28 Feb 2008

Keywords

  • Animals
  • Cell Differentiation/genetics
  • Cell Lineage/genetics
  • Cell Movement/genetics
  • Dentate Gyrus/cytology
  • Humans
  • Lateral Ventricles/cytology
  • Neurons/cytology
  • Olfactory Bulb/cytology
  • Stem Cells/cytology
  • Telencephalon/cytology

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