Development of vaccines against sea lice

R. S. Raynard, I. R. Bricknell, Peter Francis Billingsley, A. J. Nisbet, Antoine Vigneau, C. Sommerville

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    A review of efforts to develop a vaccine against sea lice is presented together with analysis of the rationale behind the approaches and potential future directions. Vaccines against the caligid copepod, Lepeophtheirus salmonis, have the potential to be a cost-effective means of controlling the infection and avoid many of the disadvantages of medicine treatments. However, research towards such vaccines is in its infancy and approaches so far used have met with little or no success. Most strategies for sea louse vaccines have adopted methods used for vaccines against other ectoparasites. A vaccine against the cattle tick (Boophilus microphis) is in field use while other vaccines such as the sheep blowfly (Lucilia cuprina) vaccine are at an earlier stage of development. These haematophageous parasites ingest host antibody as part of a large blood meal which can target antigenic sites in the gut. However, the assumption that arachnid and insect physiology are directly comparable with that of sea lice is not proven, and this may partly explain the slow progress this approach has had with sea lice. Success in developing a louse vaccine will depend upon a better understanding of louse digestive biology, particularly an evaluation of whether the cattle tick model is applicable to the development of a louse vaccine. If the louse gut is to be targeted immunologically, critical antigens will need to be identified and evaluated, bearing in mind that an economic vaccine must include recombinant proteins or be a DNA vaccine. Alternatives to the louse gut as a target are also worth consideration. Antibodies could target critical host-parasite interactions that are amenable to disruption, although no such targets have been identified. (C) 2002 Society of Chemical Industry.

    Original languageEnglish
    Pages (from-to)569-575
    Number of pages6
    JournalPest Management Science
    Volume58
    DOIs
    Publication statusPublished - 2002

    Keywords

    • Lepeophtheirus salmonis
    • sea lice
    • vaccine
    • Atlantic salmon
    • LEPEOPHTHEIRUS-SALMONIS COPEPODA
    • TICK BOOPHILUS-MICROPLUS
    • ATLANTIC SALMON
    • CALIGUS-ELONGATUS
    • EXPERIMENTAL-INFECTION
    • IMMUNOLOGICAL CONTROL
    • PROTECTIVE ANTIGEN
    • CONCEALED ANTIGENS
    • LUCILIA-CUPRINA
    • NAIVE ATLANTIC

    Cite this

    Raynard, R. S., Bricknell, I. R., Billingsley, P. F., Nisbet, A. J., Vigneau, A., & Sommerville, C. (2002). Development of vaccines against sea lice. Pest Management Science, 58, 569-575. https://doi.org/10.1002/ps.474

    Development of vaccines against sea lice. / Raynard, R. S.; Bricknell, I. R.; Billingsley, Peter Francis; Nisbet, A. J.; Vigneau, Antoine; Sommerville, C.

    In: Pest Management Science, Vol. 58, 2002, p. 569-575.

    Research output: Contribution to journalArticle

    Raynard, RS, Bricknell, IR, Billingsley, PF, Nisbet, AJ, Vigneau, A & Sommerville, C 2002, 'Development of vaccines against sea lice', Pest Management Science, vol. 58, pp. 569-575. https://doi.org/10.1002/ps.474
    Raynard RS, Bricknell IR, Billingsley PF, Nisbet AJ, Vigneau A, Sommerville C. Development of vaccines against sea lice. Pest Management Science. 2002;58:569-575. https://doi.org/10.1002/ps.474
    Raynard, R. S. ; Bricknell, I. R. ; Billingsley, Peter Francis ; Nisbet, A. J. ; Vigneau, Antoine ; Sommerville, C. / Development of vaccines against sea lice. In: Pest Management Science. 2002 ; Vol. 58. pp. 569-575.
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    AU - Raynard, R. S.

    AU - Bricknell, I. R.

    AU - Billingsley, Peter Francis

    AU - Nisbet, A. J.

    AU - Vigneau, Antoine

    AU - Sommerville, C.

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    AB - A review of efforts to develop a vaccine against sea lice is presented together with analysis of the rationale behind the approaches and potential future directions. Vaccines against the caligid copepod, Lepeophtheirus salmonis, have the potential to be a cost-effective means of controlling the infection and avoid many of the disadvantages of medicine treatments. However, research towards such vaccines is in its infancy and approaches so far used have met with little or no success. Most strategies for sea louse vaccines have adopted methods used for vaccines against other ectoparasites. A vaccine against the cattle tick (Boophilus microphis) is in field use while other vaccines such as the sheep blowfly (Lucilia cuprina) vaccine are at an earlier stage of development. These haematophageous parasites ingest host antibody as part of a large blood meal which can target antigenic sites in the gut. However, the assumption that arachnid and insect physiology are directly comparable with that of sea lice is not proven, and this may partly explain the slow progress this approach has had with sea lice. Success in developing a louse vaccine will depend upon a better understanding of louse digestive biology, particularly an evaluation of whether the cattle tick model is applicable to the development of a louse vaccine. If the louse gut is to be targeted immunologically, critical antigens will need to be identified and evaluated, bearing in mind that an economic vaccine must include recombinant proteins or be a DNA vaccine. Alternatives to the louse gut as a target are also worth consideration. Antibodies could target critical host-parasite interactions that are amenable to disruption, although no such targets have been identified. (C) 2002 Society of Chemical Industry.

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    KW - LEPEOPHTHEIRUS-SALMONIS COPEPODA

    KW - TICK BOOPHILUS-MICROPLUS

    KW - ATLANTIC SALMON

    KW - CALIGUS-ELONGATUS

    KW - EXPERIMENTAL-INFECTION

    KW - IMMUNOLOGICAL CONTROL

    KW - PROTECTIVE ANTIGEN

    KW - CONCEALED ANTIGENS

    KW - LUCILIA-CUPRINA

    KW - NAIVE ATLANTIC

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    DO - 10.1002/ps.474

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    EP - 575

    JO - Pest Management Science

    JF - Pest Management Science

    SN - 1526-498X

    ER -