Development, validity and responsiveness of the Clinical COPD Questionnaire

Thys Van Der Molen, B. W. M. Willemse, S. Schokker, N. H. T. ten Hacken, D. S. Postma, E. F. Juniper

Research output: Contribution to journalArticle

452 Citations (Scopus)

Abstract

Background
The new Global Obstructive Lung Disease (GOLD) guidelines advice to focus treatment in Chronic Obstructive Pulmonary Disease (COPD) on improvement of functional state, prevention of disease progression and minimization of symptoms. So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ).

Methods
Qualitative research with patients and clinicians was performed to generate possible items to evaluate clinical COPD control. Thereafter, an item reduction questionnaire was sent to 77 international experts. Sixty-seven experts responded and the 10 most important items, divided into 3 domains (symptoms, functional and mental state) were included in the CCQ (scale: 0 = best, 6 = worst).

Results
Cross-sectional data were collected from 119 subjects (57 COPD, GOLD stage I-III; 18 GOLD stage 0 and 44 (ex)smokers). Cronbach's a was high (0.91). The CCQ scores in patients (GOLD 0-III) were significantly higher than in healthy (ex)smokers. Furthermore, significant correlations were found between the CCQ total score and domains of the SF-36 (¿ = 0.48 to ¿ = 0.69) and the SGRQ (¿ = 0.67 to ¿ = 0.72). In patients with COPD, the correlation between the CCQ and FEV1%pred was ¿ =-0.49. Test-retest reliability was determined in 20 subjects in a 2-week interval (Intra Class Coefficient = 0.94). Thirty-six smokers with and without COPD showed significant improvement in the CCQ after 2 months smoking cessation, indicating the responsiveness of the CCQ.

Conclusion
The CCQ is a self-administered questionnaire specially developed to measure clinical control in patients with COPD. Data support the validity, reliability and responsiveness of this short and easy to administer questionnaire.
Original languageEnglish
JournalHealth and Quality of Life Outcomes
Volume1
Issue number13
DOIs
Publication statusPublished - 28 Apr 2003

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Chronic Obstructive Pulmonary Disease
Obstructive Lung Diseases
Surveys and Questionnaires
Reproducibility of Results
Smoking Cessation
Disease Progression
Guidelines

Cite this

Van Der Molen, T., Willemse, B. W. M., Schokker, S., ten Hacken, N. H. T., Postma, D. S., & Juniper, E. F. (2003). Development, validity and responsiveness of the Clinical COPD Questionnaire. Health and Quality of Life Outcomes, 1(13). https://doi.org/10.1186/1477-7525-1-13

Development, validity and responsiveness of the Clinical COPD Questionnaire. / Van Der Molen, Thys; Willemse, B. W. M.; Schokker, S.; ten Hacken, N. H. T.; Postma, D. S.; Juniper, E. F.

In: Health and Quality of Life Outcomes, Vol. 1, No. 13, 28.04.2003.

Research output: Contribution to journalArticle

Van Der Molen, T, Willemse, BWM, Schokker, S, ten Hacken, NHT, Postma, DS & Juniper, EF 2003, 'Development, validity and responsiveness of the Clinical COPD Questionnaire', Health and Quality of Life Outcomes, vol. 1, no. 13. https://doi.org/10.1186/1477-7525-1-13
Van Der Molen T, Willemse BWM, Schokker S, ten Hacken NHT, Postma DS, Juniper EF. Development, validity and responsiveness of the Clinical COPD Questionnaire. Health and Quality of Life Outcomes. 2003 Apr 28;1(13). https://doi.org/10.1186/1477-7525-1-13
Van Der Molen, Thys ; Willemse, B. W. M. ; Schokker, S. ; ten Hacken, N. H. T. ; Postma, D. S. ; Juniper, E. F. / Development, validity and responsiveness of the Clinical COPD Questionnaire. In: Health and Quality of Life Outcomes. 2003 ; Vol. 1, No. 13.
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abstract = "Background The new Global Obstructive Lung Disease (GOLD) guidelines advice to focus treatment in Chronic Obstructive Pulmonary Disease (COPD) on improvement of functional state, prevention of disease progression and minimization of symptoms. So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ). Methods Qualitative research with patients and clinicians was performed to generate possible items to evaluate clinical COPD control. Thereafter, an item reduction questionnaire was sent to 77 international experts. Sixty-seven experts responded and the 10 most important items, divided into 3 domains (symptoms, functional and mental state) were included in the CCQ (scale: 0 = best, 6 = worst). Results Cross-sectional data were collected from 119 subjects (57 COPD, GOLD stage I-III; 18 GOLD stage 0 and 44 (ex)smokers). Cronbach's a was high (0.91). The CCQ scores in patients (GOLD 0-III) were significantly higher than in healthy (ex)smokers. Furthermore, significant correlations were found between the CCQ total score and domains of the SF-36 (¿ = 0.48 to ¿ = 0.69) and the SGRQ (¿ = 0.67 to ¿ = 0.72). In patients with COPD, the correlation between the CCQ and FEV1{\%}pred was ¿ =-0.49. Test-retest reliability was determined in 20 subjects in a 2-week interval (Intra Class Coefficient = 0.94). Thirty-six smokers with and without COPD showed significant improvement in the CCQ after 2 months smoking cessation, indicating the responsiveness of the CCQ. Conclusion The CCQ is a self-administered questionnaire specially developed to measure clinical control in patients with COPD. Data support the validity, reliability and responsiveness of this short and easy to administer questionnaire.",
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AU - Van Der Molen, Thys

AU - Willemse, B. W. M.

AU - Schokker, S.

AU - ten Hacken, N. H. T.

AU - Postma, D. S.

AU - Juniper, E. F.

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N2 - Background The new Global Obstructive Lung Disease (GOLD) guidelines advice to focus treatment in Chronic Obstructive Pulmonary Disease (COPD) on improvement of functional state, prevention of disease progression and minimization of symptoms. So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ). Methods Qualitative research with patients and clinicians was performed to generate possible items to evaluate clinical COPD control. Thereafter, an item reduction questionnaire was sent to 77 international experts. Sixty-seven experts responded and the 10 most important items, divided into 3 domains (symptoms, functional and mental state) were included in the CCQ (scale: 0 = best, 6 = worst). Results Cross-sectional data were collected from 119 subjects (57 COPD, GOLD stage I-III; 18 GOLD stage 0 and 44 (ex)smokers). Cronbach's a was high (0.91). The CCQ scores in patients (GOLD 0-III) were significantly higher than in healthy (ex)smokers. Furthermore, significant correlations were found between the CCQ total score and domains of the SF-36 (¿ = 0.48 to ¿ = 0.69) and the SGRQ (¿ = 0.67 to ¿ = 0.72). In patients with COPD, the correlation between the CCQ and FEV1%pred was ¿ =-0.49. Test-retest reliability was determined in 20 subjects in a 2-week interval (Intra Class Coefficient = 0.94). Thirty-six smokers with and without COPD showed significant improvement in the CCQ after 2 months smoking cessation, indicating the responsiveness of the CCQ. Conclusion The CCQ is a self-administered questionnaire specially developed to measure clinical control in patients with COPD. Data support the validity, reliability and responsiveness of this short and easy to administer questionnaire.

AB - Background The new Global Obstructive Lung Disease (GOLD) guidelines advice to focus treatment in Chronic Obstructive Pulmonary Disease (COPD) on improvement of functional state, prevention of disease progression and minimization of symptoms. So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ). Methods Qualitative research with patients and clinicians was performed to generate possible items to evaluate clinical COPD control. Thereafter, an item reduction questionnaire was sent to 77 international experts. Sixty-seven experts responded and the 10 most important items, divided into 3 domains (symptoms, functional and mental state) were included in the CCQ (scale: 0 = best, 6 = worst). Results Cross-sectional data were collected from 119 subjects (57 COPD, GOLD stage I-III; 18 GOLD stage 0 and 44 (ex)smokers). Cronbach's a was high (0.91). The CCQ scores in patients (GOLD 0-III) were significantly higher than in healthy (ex)smokers. Furthermore, significant correlations were found between the CCQ total score and domains of the SF-36 (¿ = 0.48 to ¿ = 0.69) and the SGRQ (¿ = 0.67 to ¿ = 0.72). In patients with COPD, the correlation between the CCQ and FEV1%pred was ¿ =-0.49. Test-retest reliability was determined in 20 subjects in a 2-week interval (Intra Class Coefficient = 0.94). Thirty-six smokers with and without COPD showed significant improvement in the CCQ after 2 months smoking cessation, indicating the responsiveness of the CCQ. Conclusion The CCQ is a self-administered questionnaire specially developed to measure clinical control in patients with COPD. Data support the validity, reliability and responsiveness of this short and easy to administer questionnaire.

U2 - 10.1186/1477-7525-1-13

DO - 10.1186/1477-7525-1-13

M3 - Article

VL - 1

JO - Health and Quality of Life Outcomes

JF - Health and Quality of Life Outcomes

SN - 1477-7525

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ER -