Diabetes and pregnancy: national trends over a 15 year period

Sharon T. Mackin, Scott M. Nelson, Joannes J. Kerssens, Rachael Wood, Sarah Wild, Helen M. Colhoun, Graham P. Leese, Sam Philip, Robert S. Lindsay*, SDRN Epidemiology Grp

*Corresponding author for this work

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Abstract

Aims/hypothesis We aimed to examine time trends in national perinatal outcomes in pregnancies complicated by pre-existing type 1 or type 2 diabetes.

Methods We analysed episode-level data on all obstetric inpatient delivery events (live or stillbirth) between 1 April 1998 and 31 March 2013 (n = 813,921) using the Scottish Morbidity Record (SMR02). Pregnancies to mothers with type 1 (n = 3229) and type 2 (n = 1452) diabetes were identified from the national diabetes database (Scottish Care Information-Diabetes), and perinatal outcomes were compared among women with type 1 diabetes, type 2 diabetes and those without diabetes.

Results The number of pregnancies complicated by diabetes increased significantly, by 44% in type 1 diabetes and 90% in type 2 diabetes, across the 15 years examined, to rates of 1 in 210 and 1 in 504 deliveries, respectively. Compared with women without diabetes, delivery occurred 2.6 weeks earlier (type 1 diabetes 36.7 +/- 2.3 weeks) and 2 weeks earlier (type 2 diabetes 37.3 +/- 2.4 weeks), respectively, showing significant reductions for both type 1 (from 36.7 weeks to 36.4 weeks, p = 0.03) and type 2 (from 38.0 weeks to 37.2 weeks, p <0.001) diabetes across the time period. The proportions of preterm delivery were markedly increased in women with diabetes (35.3% type 1 diabetes, 21.8% type 2 diabetes, 6.1% without diabetes; p <0.0001), and these proportions increased with time for both groups (p <0.005). Proportions of elective Caesarean sections (29.4% type 1 diabetes, 30.5% type 2 diabetes, 9.6% without diabetes) and emergency Caesarean sections (38.3% type 1 diabetes, 29.1% type 2 diabetes, 14.6% without diabetes) were greatly increased in women with diabetes and increased over time except for stable rates of emergency Caesarean section in type 1 diabetes. Gestational age-, sex- and parity-adjusted z score for birthweight (1.33 +/- 1.34; p <0.001) were higher in type 1 diabetes and increased over time from 1.22 to 1.47 (p <0.001). Birthweight was also increased in type 2 diabetes (0.94 +/- 1.34; p <0.001) but did not alter with time. There were 65 perinatal deaths in offspring of mothers with type 1 diabetes and 39 to mothers with type 2 diabetes, representing perinatal mortality rates of 20.1 (95% CI 14.7, 24.3) and 26.9 (16.7, 32.9) per 1000 births, respectively, and rates 3.1 and 4.2 times, respectively, those observed in the non-diabetic population (p <0.001). Stillbirth rates in type 1 and type 2 diabetes were 4.0-fold and 5.1-fold that in the non-diabetic population (p <0.001). Perinatal mortality and stillbirth rates showed no significant fall over time despite small falls in the rates for the non-diabetic population.

Conclusions/interpretation Women with diabetes are receiving increased intervention in pregnancy (earlier delivery, increased Caesarean section rates), but despite this, higher birthweights are being recorded. Improvements in rates of stillbirth seen in the general population are not being reflected in changes in stillbirth or perinatal mortality in our population with diabetes.

Original languageEnglish
Pages (from-to)1081-1088
Number of pages8
JournalDiabetologia
Volume61
Issue number5
Early online date11 Jan 2018
DOIs
Publication statusPublished - May 2018

Keywords

  • Diabetes
  • Epidemiology
  • Perinatal
  • Pregnancy
  • Trends
  • Type 1 diabetes
  • Type 2 diabetes
  • Type-1
  • Women
  • Outcomes
  • Netherlands
  • Mortality
  • Scotland

Cite this

Mackin, S. T., Nelson, S. M., Kerssens, J. J., Wood, R., Wild, S., Colhoun, H. M., Leese, G. P., Philip, S., Lindsay, R. S., & SDRN Epidemiology Grp (2018). Diabetes and pregnancy: national trends over a 15 year period. Diabetologia, 61(5), 1081-1088. https://doi.org/10.1007/s00125-017-4529-3