TY - CHAP
T1 - Diabetes, Mitochondria and brain endothelium dysfunction
T2 - a dangerous triad for neurodegeneration?
AU - Carvalho, Cristina
AU - Correia, Sónia C
AU - Coelho Dos Santos, Renato Xavier
AU - Cardoso, Susana
AU - Santos, Maria Sancha
AU - da Silva Moreira, Paula Isabel
PY - 2011
Y1 - 2011
N2 - Diabetes is a chronic disease that results from a complex interplay between genetic predisposition and environmental factors and is considered one of the main threats to human health. Neurodegenerative processes such as brain atrophy, white matter and vascular abnormalities, cognitive impairment and dementia are present in a high percentage of diabetic patients. Vascular endothelial dysfunction is accompanied by an imbalance between vasodilator and vasoconstrictor substances produced by the endothelium. Although the way how endothelial function is altered in diabetes is not yet fully understood, the literature suggests that mitochondria play an important role in this process. This review is aimed to discuss the role of brain endothelium in physiologic and diabetes-associated pathologic conditions. The role of mitochondria, oxidative stress and insulin signalling in diabetes-induced endothelium dysfunction is also debated. Finally, some potential therapeutic strategies aimed to counteract diabetes-related endothelium dysfunction will be briefly discussed.
AB - Diabetes is a chronic disease that results from a complex interplay between genetic predisposition and environmental factors and is considered one of the main threats to human health. Neurodegenerative processes such as brain atrophy, white matter and vascular abnormalities, cognitive impairment and dementia are present in a high percentage of diabetic patients. Vascular endothelial dysfunction is accompanied by an imbalance between vasodilator and vasoconstrictor substances produced by the endothelium. Although the way how endothelial function is altered in diabetes is not yet fully understood, the literature suggests that mitochondria play an important role in this process. This review is aimed to discuss the role of brain endothelium in physiologic and diabetes-associated pathologic conditions. The role of mitochondria, oxidative stress and insulin signalling in diabetes-induced endothelium dysfunction is also debated. Finally, some potential therapeutic strategies aimed to counteract diabetes-related endothelium dysfunction will be briefly discussed.
M3 - Chapter (peer-reviewed)
SN - 9781616683467
T3 - Cell Biology Research Progress
SP - 553
EP - 578
BT - Mitochondria
A2 - Svensson, Oliver L.
PB - Nova Science Publishers Inc
ER -
