Diabetes, Mitochondria and brain endothelium dysfunction: a dangerous triad for neurodegeneration?

Cristina Carvalho, Sónia C Correia, Renato Xavier Coelho Dos Santos, Susana Cardoso, Maria Sancha Santos, Paula Isabel da Silva Moreira

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

1 Citation (Scopus)

Abstract

Diabetes is a chronic disease that results from a complex interplay between genetic predisposition and environmental factors and is considered one of the main threats to human health. Neurodegenerative processes such as brain atrophy, white matter and vascular abnormalities, cognitive impairment and dementia are present in a high percentage of diabetic patients. Vascular endothelial dysfunction is accompanied by an imbalance between vasodilator and vasoconstrictor substances produced by the endothelium. Although the way how endothelial function is altered in diabetes is not yet fully understood, the literature suggests that mitochondria play an important role in this process. This review is aimed to discuss the role of brain endothelium in physiologic and diabetes-associated pathologic conditions. The role of mitochondria, oxidative stress and insulin signalling in diabetes-induced endothelium dysfunction is also debated. Finally, some potential therapeutic strategies aimed to counteract diabetes-related endothelium dysfunction will be briefly discussed.
Original languageEnglish
Title of host publicationMitochondria
Subtitle of host publicationStructure, Functions and Dysfunctions
EditorsOliver L. Svensson
PublisherNova Science Publishers Inc
Chapter10
Pages553-578
Number of pages26
ISBN (Print)9781616683467
Publication statusPublished - 2011

Publication series

NameCell Biology Research Progress
PublisherNova Science Publishers

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Carvalho, C., Correia, S. C., Coelho Dos Santos, R. X., Cardoso, S., Santos, M. S., & da Silva Moreira, P. I. (2011). Diabetes, Mitochondria and brain endothelium dysfunction: a dangerous triad for neurodegeneration? In O. L. Svensson (Ed.), Mitochondria: Structure, Functions and Dysfunctions (pp. 553-578). (Cell Biology Research Progress). Nova Science Publishers Inc.