Diabetes is a chronic disease that results from a complex interplay between genetic predisposition and environmental factors and is considered one of the main threats to human health. Neurodegenerative processes such as brain atrophy, white matter and vascular abnormalities, cognitive impairment and dementia are present in a high percentage of diabetic patients. Vascular endothelial dysfunction is accompanied by an imbalance between vasodilator and vasoconstrictor substances produced by the endothelium. Although the way how endothelial function is altered in diabetes is not yet fully understood, the literature suggests that mitochondria play an important role in this process. This review is aimed to discuss the role of brain endothelium in physiologic and diabetes-associated pathologic conditions. The role of mitochondria, oxidative stress and insulin signalling in diabetes-induced endothelium dysfunction is also debated. Finally, some potential therapeutic strategies aimed to counteract diabetes-related endothelium dysfunction will be briefly discussed.
|Title of host publication||Mitochondria|
|Subtitle of host publication||Structure, Functions and Dysfunctions|
|Editors||Oliver L. Svensson|
|Publisher||Nova Science Publishers Inc|
|Number of pages||26|
|Publication status||Published - 2011|
|Name||Cell Biology Research Progress|
|Publisher||Nova Science Publishers|
Carvalho, C., Correia, S. C., Coelho Dos Santos, R. X., Cardoso, S., Santos, M. S., & da Silva Moreira, P. I. (2011). Diabetes, Mitochondria and brain endothelium dysfunction: a dangerous triad for neurodegeneration? In O. L. Svensson (Ed.), Mitochondria: Structure, Functions and Dysfunctions (pp. 553-578). (Cell Biology Research Progress). Nova Science Publishers Inc.